| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Olomoucine II - CAS 500735-47-7 - Calbiochem
|
| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
|
| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
CAS:500735-47-7
Purity:大于98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
|
OLOMOUCINE II manufacturers
- Olomoucine II
-
- $159.00 / 1mg
-
2025-12-22
- CAS:500735-47-7
- Min. Order:
- Purity: 99.94%
- Supply Ability: 10g
|
| | OLOMOUCINE II Basic information |
| Product Name: | OLOMOUCINE II | | Synonyms: | Olomoucine II - CAS 500735-47-7 - Calbiochem;Nsc736738;Olomoucine ii, 6-[(2-hydroxybenzyl)amino]-2-[1-(hydroxymethyl)propylamino]- 9-isopropylpurine;2-[[[2-[[(1R)-1-(Hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]phenol;Phenol, 2-[[[2-[[(1R)-1-(hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]-;Olomoucine II, CDK/cyclin inhibitor | | CAS: | 500735-47-7 | | MF: | C19H26N6O2 | | MW: | 370.45 | | EINECS: | | | Product Categories: | | | Mol File: | 500735-47-7.mol |  |
| | OLOMOUCINE II Chemical Properties |
| Boiling point | 618.5±65.0 °C(Predicted) | | density | 1.32 | | storage temp. | −20°C | | solubility | chloroform: 50 mg/mL, soluble | | form | powder | | pka | 9.83±0.30(Predicted) | | color | colorless |
| | OLOMOUCINE II Usage And Synthesis |
| Uses | Olomoucine II is a potent CDK inhibitor with IC50 values of 0.06, 0.1, 0.45, 7.6, 19.8 μM for CDK9/cyclin T, CDK2/cyclin E, CDK7/cyclin H, CDK1/cyclin B, CDK4/cyclin D1, respectively. Olomoucine II shows antiproliferative activity[1]. | | Definition | ChEBI: 2-[[[2-(1-hydroxybutan-2-ylamino)-9-propan-2-yl-6-purinyl]amino]methyl]phenol is a thiopurine. | | General Description | A cell-permeable 2,6,9-trisubstituted purine analog that acts as a potent, reversible, and ATP-competitive inhibitor of Cdk1/B with an IC50 of 20 nM and displays increased potency over purvalanol A (Cat. No. 540500; IC50 = 50 nM), Roscovitine (Cat. No. 557360; IC50 = 450 nM), Bohemine (Cat. No. 203600; IC50 = 1.1 μM) and Olomoucine (Cat. No. 495620; IC50 = 7.0 μM). Further, exerts greater in vitro cytotoxicity in various cancer cell lines (IC50 = 3.0 μM, 5.3 μM, 6.3 μM, 6.3 μM and 11.1 μM for CEM, MCF7, HOS, G631 and K562, respectively). | | Biochem/physiol Actions | Cell permeable: yes | | IC 50 | CDK9/cycT: 0.06 μM (IC50); CDK2/cyclinE: 0.1 μM (IC50); CDK7/cyclin H: 0.45 μM (IC50); Cdk1/cyclin B: 7.6 μM (IC50); CDK4/cyclinD1: 19.8 μM (IC50) | | References | [1] Krystof V, et al. Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor. Cell Mol Life Sci. 2005 Aug;62(15):1763-71. DOI:10.1007/s00018-005-5185-1 |
| | OLOMOUCINE II Preparation Products And Raw materials |
|