Aminopurvalanol a manufacturers
- Aminopurvalanol A
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- $35.00
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2026-07-27
- CAS:220792-57-4
- Purity: 99.73%
- Supply Ability: 10g
- AMINOPURVALANOL A
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2026-07-13
- CAS:220792-57-4
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1000kg
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| | Aminopurvalanol a Basic information |
| Product Name: | Aminopurvalanol a | | Synonyms: | NG-97;(2R)-2-[[6-[(3-AMINO-5-CHLOROPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL;AMINOPURVALANOL A (APURV);1-Butanol, 2-[[6-[(3-amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-, (2R)-;(R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-isopropyl-9H-purin-2-yl)amino)-3-methylbutan-1-ol;inhibit,actin polymerization,Inhibitor,Cyclins,cancer cell differention,G2/M-phase transition,Apoptosis,Aminopurvalanol A,Cyclin dependent kinase,CDK,sperm fertilizing ability;Aminopurvalanol A, cyclin-dependent kinase inhibitor;Aminopurvalanol A, 10 mM in DMSO | | CAS: | 220792-57-4 | | MF: | C19H26ClN7O | | MW: | 403.91 | | EINECS: | | | Product Categories: | | | Mol File: | 220792-57-4.mol |  |
| | Aminopurvalanol a Chemical Properties |
| Boiling point | 639.0±65.0 °C(Predicted) | | density | 1.40±0.1 g/cm3(Predicted) | | storage temp. | Store at +4°C | | solubility | Soluble to 100 mM in DMSO | | form | White to brownish solid. | | pka | 14.51±0.10(Predicted) | | color | Off-white to light yellow | | InChI | 1S/C19H26ClN7O/c1-10(2)15(8-28)24-19-25-17(23-14-6-12(20)5-13(21)7-14)16-18(26-19)27(9-22-16)11(3)4/h5-7,9-11,15,28H,8,21H2,1-4H3,(H2,23,24,25,26)/t15-/m0/s1 | | InChIKey | RAMROQQYRRQPDL-HNNXBMFYSA-N |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | Aminopurvalanol a Usage And Synthesis |
| Uses | Aminopurvalanol A is a reversible and ATP-competitive inhibitor of Cdks. | | Definition | ChEBI: Aminopurvalanol is a purvalanol and a member of monochlorobenzenes. It has a role as a protein kinase inhibitor. | | Biological Activity | Cell-permeable cyclin-dependent kinase inhibitor. IC 50 values are 0.033, 0.033, 0.028 and 0.020 μ M for cdk1/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5/p35 respectively. Inhibits ERK1 (IC 50 = 12.0 μ M) and ERK2 (IC 50 = 3.1 μ M) and is 3000-fold selective over a range of other protein kinases (IC 50 > 100 μ M). Arrests cell cycle at G 2 /M boundary (IC 50 = 1.25 μ M), and induces apoptosis at concentrations > 10 μ M. | | Enzyme inhibitor | This cell-permeable purvalanol derivative (FW = 403.92 g/mol), also named (2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methylethyl)- 9H-purin-2-yl]amino]-3-methyl-1-butanol, targets cdk1/cyclin B (IC50 = 0.033 μM), cdk2/cyclin A (IC50 = 0.033 μM), cdk2/cyclin E (IC50 = 0.028 μM), and cdk5/p35 (IC50 = 0.020 μM). It also inhibits ERK1 (IC50 = 12 μM) and ERK2 (IC50 = 3.1 μM), with 3000-times greater selectivity versus a range of other protein kinases (IC50 > 100 μM). Aminopurvalanol A arrests cell cycle at G2/M boundary (IC50 = 1.25 μM), and induces apoptosis at concentrations > 10 μM. | | storage | Store at +4°C |
| | Aminopurvalanol a Preparation Products And Raw materials |
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