- Ro-3306
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- $30.00
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2026-05-29
- CAS:872573-93-8
- Purity: 99.79%
- Supply Ability: 10g
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| | Ro 3306 Basic information |
| Product Name: | Ro 3306 | | Synonyms: | Ro 3306;2-[[(Thiophen-2-yl)methyl]amino]-5-[1-(quinolin-6-yl)meth-(Z)-ylidene]thiazol-4-one;(Z)-5-(quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one;(5Z)-5-Quinolin-6-ylmethylene-2-[(thiophen-2-ylmethyl)-amino]-thiazol-4-one;5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone;RO3306;RO 3306;4(5H)-Thiazolone, 5-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-, (5Z)-;(5Z)-5-(quinolin-6-ylmethylidene)-2-(thiophen-2-ylmethylamino)-1,3-thiazol-4-one | | CAS: | 872573-93-8 | | MF: | C18H13N3OS2 | | MW: | 351.45 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 872573-93-8.mol |  |
| | Ro 3306 Chemical Properties |
| Boiling point | 569.1±60.0 °C(Predicted) | | density | 1.41 | | storage temp. | 2-8°C | | solubility | DMSO: soluble5mg/mL, clear | | pka | 3.99±0.10(Predicted) | | form | powder | | color | white to light brown | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. | | InChI | 1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)/b16-10- | | InChIKey | XOLMRFUGOINFDQ-YBEGLDIGSA-N | | SMILES | O=C1N=C(NCC2=CC=CS2)S/C1=C\C3=CC4=C(C=C3)N=CC=C4 |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | Ro 3306 Usage And Synthesis |
| Description | RO-3306 (872573-93-8) is a selective inhibitor of CDK1 (IC50= 35 nM versus CDK2 IC50= 340nM).1,2It induces G2/M phase cell cycle arrest and apoptosis. Inhibition of CDK1 with RO-3306 has been shown to have synergistic effects with PARP inhibitors in treating various breast cancers.3,4It has also been demonstrated to overcome apoptotic resistance in BRAFV600Ehuman colorectal cancer cells.5 | | Uses | RO-3306 is an ATP-competitive and selective CDK1 inhibitor used against a diverse panel of human kinases. Used in the treatment of malignant tumors in conjunction with PARP inhibitors. | | Uses | RO-3306 has been used:
- To study the significance of CA4-mediated cytotoxicity in mitotic arrest
- In cell cycle synchronization to conduct a study on proteomics
- As a CDK1 inhibitor, to prevent early mitotic entry
| | Biochem/physiol Actions | RO-3306 is a selective ATP-competitive inhibitor of CDK1. It inhibites CDK1 cyclin B1 activity with Ki of 35 nM, nearly 10-fold selectivity relative to CDK2/cyclin E and over 50-fold relative to CDK4/cyclin D. RO-3306 has been used to cause cell cycle arrest at the G2/M boundary. | | IC 50 | CDK1: 20 nM (Ki); CDK1/cyclinB1: 35 nM (Ki); CDK1/cyclin A: 110 nM (Ki); CDK2/cyclinE: 340 nM (Ki); PKCδ: 318 nM (Ki); SGK: 497 nM (Ki); ERK: 1980 nM (Ki) | | storage | Store at +4°C | | References | [1] LYUBOMIR T VASSILEV. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2006: 10660-10665. DOI:10.1073/pnas.0600447103
[2] LILIANA KRASINSKA Daniel F Emilie Cot. Selective chemical inhibition as a tool to study Cdk1 and Cdk2 functions in the cell cycle.[J]. Cell Cycle, 2008: 1702-1708. DOI:10.4161/cc.7.12.6101
[3] AISLING PIERCE. Comparative antiproliferative effects of iniparib and olaparib on a panel of triple-negative and non-triple-negative breast cancer cell lines.[J]. Cancer Biology & Therapy, 2013, 14 6: 537-545. DOI:10.4161/cbt.24349
[4] QING XIA. The CDK1 inhibitor RO3306 improves the response of BRCA-proficient breast cancer cells to PARP inhibition.[J]. International journal of oncology, 2014, 44 3: 735-744. DOI:10.3892/ijo.2013.2240
[5] PENG ZHANG. Targeting CDK1 and MEK/ERK Overcomes Apoptotic Resistance in BRAF-Mutant Human Colorectal Cancer.[J]. Molecular Cancer Research, 2018, 16 3: 378-389. DOI:10.1158/1541-7786.mcr-17-0404 |
| | Ro 3306 Preparation Products And Raw materials |
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