- 4-Pyrazol-1-yl-phenylamine
-
- $0.00 / 1KG
-
2022-01-04
- CAS:17635-45-9
- Min. Order: 1g
- Purity: 98%min
- Supply Ability: 4-Pyrazol-1-yl-phenylamine
|
| | 4-(1H-Pyrazol-1-yl)aniline Basic information |
| | 4-(1H-Pyrazol-1-yl)aniline Chemical Properties |
| Melting point | 54 °C | | Boiling point | 312.0±25.0 °C(Predicted) | | density | 1.20±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | solid | | pka | 4.03±0.10(Predicted) | | Appearance | Gray to brown Solid | | InChI | InChI=1S/C9H9N3/c10-8-2-4-9(5-3-8)12-7-1-6-11-12/h1-7H,10H2 | | InChIKey | CSFIQHZIFKIQNO-UHFFFAOYSA-N | | SMILES | C1(N)=CC=C(N2C=CC=N2)C=C1 | | CAS DataBase Reference | 17635-45-9(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36/37/39-37/39 | | WGK Germany | WGK 3 | | HazardClass | IRRITANT | | HS Code | 2921420090 | | Storage Class | 11 - Combustible Solids |
| | 4-(1H-Pyrazol-1-yl)aniline Usage And Synthesis |
| Synthesis | GENERAL STEPS: In a typical reaction, 5.0 mg of Pd-gCN catalyst (containing 5.0 wt% Pd) was mixed with 1.0 mM 1-(4-nitrophenyl)-1H-pyrazole in ethanol (2 mL) and 60% hydrazine hydrate solution (2 mM, 1.2 equiv, 0.07 mL). The mixture was placed in a 10 mL round-bottomed flask and reacted at reflux temperature (70°C) for 4 hours, followed by cooling to room temperature. After completion of the reaction, the reaction mixture was filtered and the filtrate was purified by silica gel column chromatography to afford 4-(1H-pyrazol-1-yl)aniline (1-(4-aminophenyl)pyrazole). For dinitroaromatic substrates, 4.0 mM (2.4 eq., 0.14 mL) of 60% hydrazine hydrate solution is required. | | References | [1] Chemical and Pharmaceutical Bulletin, 2000, vol. 48, # 12, p. 1935 - 1946
[2] Applied Catalysis A: General, 2016, vol. 523, p. 31 - 38
[3] Patent: EP3159340, 2017, A1. Location in patent: Paragraph 0086; 0091
[4] Patent: US2015/336982, 2015, A1. Location in patent: Paragraph 0165; 0167
[5] Patent: CN105418590, 2016, A. Location in patent: Paragraph 0152; 0153; 0154 |
| | 4-(1H-Pyrazol-1-yl)aniline Preparation Products And Raw materials |
|