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| | 3,4-DIAMINOBENZOTRIFLUORIDE Basic information |
| | 3,4-DIAMINOBENZOTRIFLUORIDE Chemical Properties |
| Melting point | 56-58 °C | | Boiling point | 253℃ | | density | 1.381 | | Fp | 111℃ | | storage temp. | 2-8°C(protect from light) | | pka | 2.94±0.10(Predicted) | | form | powder | | color | Light brown to brown | | Water Solubility | Miscible with water. | | BRN | 909258 | | CAS DataBase Reference | 368-71-8(CAS DataBase Reference) |
| Hazard Codes | Xn,Xi | | Risk Statements | 36/37/38-20/21/22-22 | | Safety Statements | 36/37/39-26 | | RIDADR | 2811 | | Hazard Note | Harmful/Irritant | | HazardClass | IRRITANT-HARMFUL | | HazardClass | 6.1 | | PackingGroup | Ⅲ | | HS Code | 29215900 |
| | 3,4-DIAMINOBENZOTRIFLUORIDE Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powder | | Uses | 3,4-Diaminobenzotrifluoride is commonly used as pharmaceutical intermediate. | | Synthesis | The reaction was carried out in anhydrous ethanol (50 mL) at reflux for 45 minutes with 4-amino-3-nitrobenzotrifluoride (5.000 g, 24.26 mmol, Aldrich, direct use) and SnCl2-2H2O (20.00 g, 88.64 mmol, Aldrich, direct use). Upon completion of the reaction, the mixture was poured into ice (85 g) and alkalized with 10% aqueous NaHCO3 (250 mL). Subsequently, the resulting suspension was extracted with ethyl acetate (400 mL). The ethyl acetate extracts were combined, dried with Na2SO4, and the solvent was evaporated under reduced pressure to give 4.14 g (87% yield) of pure 4-trifluoromethyl-1,2-phenylenediamine as a red powder. | | References | [1] Patent: US5514680, 1996, A |
| | 3,4-DIAMINOBENZOTRIFLUORIDE Preparation Products And Raw materials |
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