| Company Name: |
Cochemical Ltd. |
| Tel: |
029-86115547 17791676824 |
| Email: |
sales@cochemical.com |
- Altizide
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- $1980.00
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2026-05-11
- CAS:5588-16-9
- Purity:
- Supply Ability: 10g
- Althiazide
-
-
2025-12-24
- CAS:5588-16-9
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 1000kg
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| | Althiazide Basic information |
| Product Name: | Althiazide | | Synonyms: | ALTHIAZIDE;6-CHLORO-3,4-DIHYDRO-3-[(2-PROPENYLTHIO)METHYL]-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE;6-chloro-1,1-dioxo-3-(prop-2-enylsulfanylmethyl)-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide;6-chloro-1,1-dioxo-3-(prop-2-enylsulfanylmethyl)-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide;3-[(Allylthio)methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;P-1779;3-[(allylthio)methyl]-6-chloro-1,1-diketo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide;6-chloro-1,1-dioxo-3-(prop-2-enylsulfanylmethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide | | CAS: | 5588-16-9 | | MF: | C11H14ClN3O4S3 | | MW: | 383.89 | | EINECS: | 226-994-8 | | Product Categories: | Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium | | Mol File: | 5588-16-9.mol |  |
| | Althiazide Chemical Properties |
| Melting point | 206-207° | | Boiling point | 625.8±65.0 °C(Predicted) | | density | 1.502±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Practically insoluble in water, soluble in methanol, practically insoluble in dichloromethane. | | pka | 8.33±0.40(Predicted) | | color | White to Off-White | | Major Application | pharmaceutical (small molecule) | | InChI | 1S/C11H14ClN3O4S3/c1-2-3-20-6-11-14-8-4-7(12)9(21(13,16)17)5-10(8)22(18,19)15-11/h2,4-5,11,14-15H,1,3,6H2,(H2,13,16,17) | | InChIKey | VGLGVJVUHYTIIU-UHFFFAOYSA-N | | SMILES | NS(=O)(=O)c1cc2c(NC(CSCC=C)NS2(=O)=O)cc1Cl | | EPA Substance Registry System | 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-[(2-propen-1-ylthio)methyl]-, 1,1-dioxide (5588-16-9) |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | Althiazide Usage And Synthesis |
| Description | Althiazide, also known as altizide, is an agent belonging to the class of thiazide diuretics with antihypertensive activity. This aldosterone antagonist is often combined with spironolactone. | | Chemical Properties | White Solid | | Originator | Althiazide,Solchem | | Uses | Diuretic and antihypertensive. | | Definition | ChEBI: Althiazide is a benzothiadiazine. It is the thiazide and sulfonamide derivative. | | Manufacturing Process | To 6.75 g (0.0225 mole) of 4-amino-2-chloro-5-(methylsulfamyl)
benzenesulfonamide in 45 ml of dimethylformamide is added 4.86 g (0.03
mole) of dimethyl allylmercaptoacetal followed by 1.5 ml ethyl acetate
saturated with hydrogen chloride gas. The solution is refluxed for 1.5 hours,
cooled and added dropwise with stirring to ice/water. The resulting precipitate
is filtered, dried and recrystallized from isopropanol. The recrystallization gave
4.0 g of 2-methyl-3-allylthiomethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-
benzothiadiazine-1,1-dioxide; M.P. 168.5-170°C. | | Therapeutic Function | Diuretic, Antihypertensive |
| | Althiazide Preparation Products And Raw materials |
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