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| | 2-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID Basic information |
| Product Name: | 2-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID | | Synonyms: | 2-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID;BUTTPARK 24\07-92;Benzoic acid, 2-amino-5-(trifluoromethyl)-;4-Amino-3-carboxybenzotrifluoride, 2-Carboxy-4-(trifluoromethyl)aniline;2-Amino-5-trifuloromethylbenzoic acid;4-Amino-3-carboxybenzotrifluoride;2-Amino-5-(trifluoromethyl)benzoic acid 98%;2-Amino-5-(trifluoromethyl)benzoicacid,95% | | CAS: | 83265-53-6 | | MF: | C8H6F3NO2 | | MW: | 205.1339496 | | EINECS: | 207-163-9 | | Product Categories: | Fluorine series;Benzoic acid series | | Mol File: | 83265-53-6.mol |  |
| | 2-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID Chemical Properties |
| Melting point | 141-146℃ | | Boiling point | 301.6±42.0 °C(Predicted) | | density | 1.489±0.06 g/cm3(Predicted) | | Fp | >110°(230°F) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 4.51±0.10(Predicted) | | form | Solid | | Appearance | White to light yellow Solid |
| Hazard Codes | Xi | | Hazard Note | Irritant | | HS Code | 2916399090 |
| | 2-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID Usage And Synthesis |
| Uses | 2-amino-5-(trifluoromethyl)benzoic Acid is a benzoic acid derivative whose molecular structure contains substituents amino and trifluoromethyl at positions 2 and 5. The substance can be used to prepare small molecule inhibitors or anticancer drugs, and is widely used in fields such as chemical or pharmaceutical manufacturing. | | Synthesis | Step 2 Synthesis of 2-amino-5-(trifluoromethyl)benzoic acid: 2-nitro-5-(trifluoromethyl)benzoic acid (1.2 g, 4.78 mmol) was suspended in ethanol (10 mL) and 10% Pd/C catalyst (120 mg) was added. The hydrogenation reaction was carried out at room temperature and atmospheric pressure for 1 hour. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated to afford 2-amino-5-(trifluoromethyl)benzoic acid (900 mg, 85.2% yield) as a pale white solid. The resulting product could be used in subsequent reactions without further purification. | | References | [1] Patent: WO2016/23826, 2016, A1. Location in patent: Page/Page column 52; 53 |
| | 2-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID Preparation Products And Raw materials |
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