3-Amino-5-(trifluoromethyl)benzoic acid manufacturers
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| | 3-Amino-5-(trifluoromethyl)benzoic acid Basic information |
| | 3-Amino-5-(trifluoromethyl)benzoic acid Chemical Properties |
| Melting point | 141-146 °C(lit.) | | Boiling point | 331.9±42.0 °C(Predicted) | | density | 1.489±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | powder to crystal | | pka | 3.93±0.10(Predicted) | | color | Light yellow to Yellow to Orange | | CAS DataBase Reference | 328-68-7(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS | DD6205700 | | HazardClass | IRRITANT | | HS Code | 2934999090 |
| | 3-Amino-5-(trifluoromethyl)benzoic acid Usage And Synthesis |
| Uses | peptide synthesis | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | The suspension formed by 3-nitro-5-(trifluoromethyl)benzoic acid (103 g x 2 batches) obtained in step 1 and 10% palladium-carbon catalyst (5.15 g x 2 batches) in ethanol (1500 mL x 2 batches) was placed under the atmosphere of hydrogen at 1 atmospheric pressure, and the reaction was stirred for 7 hours at room temperature. After completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford the target product 3-amino-5-(trifluoromethyl)benzoic acid (180 g, 100% yield) as a light yellow powder. The product was characterized by 1H-NMR (300 MHz, CDCl3): δ 4.00-6.00 (2H, broad peak), 7.10 (1H, single peak), 7.53 (1H, single peak), 7.72 (1H, single peak). | | References | [1] Patent: US2008/275085, 2008, A1. Location in patent: Page/Page column 45
[2] Chemistry - A European Journal, 2017, vol. 23, # 52, p. 12758 - 12762
[3] Patent: US2007/213371, 2007, A1. Location in patent: Page/Page column 70
[4] Journal of the American Chemical Society, 2017, vol. 139, # 43, p. 15308 - 15311
[5] Patent: WO2004/29038, 2004, A1. Location in patent: Page 44 |
| | 3-Amino-5-(trifluoromethyl)benzoic acid Preparation Products And Raw materials |
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