- Protopanaxadiol
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- $8.00
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2020-02-21
- CAS:7755-01-3
- Min. Order: 1g
- Purity: ＞98% HPLC
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| | Protopanaxadiol Basic information |
| Product Name: | Protopanaxadiol | | Synonyms: | Protopanaxadiol, 98%, from Panax ginseng C. A. Mey.;Protopanaxadiol;20R-Betulafolienetriol;(20R)-5α-Dammar-24-ene-3β,12β,20-triol;(20R)-Dammar-24-ene-3β,12β,20-triol;20R-Protopanaxadiol;PROTOVERATRINE A+B (RG)(CALL);Dammar-24-ene-3,12,20-triol, (3β,12β,20R)- | | CAS: | 7755-01-3 | | MF: | C30H52O3 | | MW: | 460.73 | | EINECS: | | | Product Categories: | Ginseng series;Miscellaneous Natural Products | | Mol File: | 7755-01-3.mol |  |
| | Protopanaxadiol Chemical Properties |
| Melting point | 244-245 °C(Solvent: Ethyl acetate) | | Boiling point | 559.5±40.0 °C(Predicted) | | density | 1.036±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | powder | | pka | 14.96±0.70(Predicted) | | color | White | | LogP | 7.590 (est) |
| | Protopanaxadiol Usage And Synthesis |
| Description | (20)R-Protopanaxadiol is a sapogenin that has been found in P. ginseng and has anticancer and antibacterial activities. It has a cytotoxic concentration (CC50) value of 6.1 μM in MT-4 human T cell leukemia cells and inhibits the growth of several additional cancer cell lines, including A549 human lung carcinoma, SKOV3 human ovarian adenocarcinoma, SK-Mel-2 human melanoma, P388 and L1210 murine leukemia, and K562 human chronic leukemia cells (ED50s = 11-26 μM). (20)R-protopanaxadiol also inhibits the growth of H. pylori in vitro (MICs = 50-100 μg/ml). | | Chemical Properties | White powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from ginseng. | | Uses | 20(R)-Protopanaxdiol is a saponin ginsenoside which is a signature phytochemical of Ginseng, an herbaceous plant. Anti-cancer agent. | | Definition | ChEBI: A diastereomer of protopanaxadiol in which the 20-hydroxy substituent has been introduced at the pro-R position. | | References | [1] N. BAEK. Cytotoxicities of ginseng saponins and their degradation products against some cancer cell lines[J]. Archives of Pharmacal Research, 1995, 18 1: 164-168. DOI: 10.1007/bf02979189
[2] H HASEGAWA. Inhibitory effect of some triterpenoid saponins on glucose transport in tumor cells and its application to in vitro cytotoxic and antiviral activities.[J]. Planta medica, 1994, 60 3: 240-243. DOI: 10.1055/s-2006-959467
[3] E. BAE. Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities.[J]. Biological & pharmaceutical bulletin, 2002, 20 1: 58-63. DOI: 10.1248/bpb.25.58 |
| | Protopanaxadiol Preparation Products And Raw materials |
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