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| | ETHANOLAMINE HYDROCHLORIDE Basic information |
| | ETHANOLAMINE HYDROCHLORIDE Chemical Properties |
| Melting point | 82-84 °C(lit.) | | density | 1.07g/cm3 at 20—25°C
1.12g/cm3 at 20—25°C | | storage temp. | Store below +30°C. | | solubility | DMSO (Slightly, Heated) | | form | Agglomerating Crystals | | color | White or slightly beige | | Specific Gravity | 1.146 | | Odor | Odorless | | PH | 9—10 | | pka | 9.5(at 25℃) | | Water Solubility | almost transparency | | Sensitive | Hygroscopic | | Merck | 14,3727 | | BRN | 3542892 | | Stability: | Hygroscopic | | Cosmetics Ingredients Functions | BUFFERING | | Cosmetic Ingredient Review (CIR) | ETHANOLAMINE HYDROCHLORIDE (2002-24-6) | | InChI | 1S/C2H7NO.ClH/c3-1-2-4;/h4H,1-3H2;1H | | InChIKey | PMUNIMVZCACZBB-UHFFFAOYSA-N | | SMILES | NCCO.[H]Cl | | LogP | -1.308 (est) | | CAS DataBase Reference | 2002-24-6(CAS DataBase Reference) | | EPA Substance Registry System | Ethanol, 2-amino-, hydrochloride (2002-24-6) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36/37/39 | | WGK Germany | 1 | | RTECS | KJ6370000 | | F | 3-10 | | TSCA | TSCA listed | | HS Code | 29221100 | | Storage Class | 11 - Combustible Solids |
| | ETHANOLAMINE HYDROCHLORIDE Usage And Synthesis |
| Chemical Properties | White or slightly beige agglomerating crystals | | Uses | Ethanolamine hydrochloride has been used:
- in overnight incubation of the tips to attach primary amine groups at the tip surface
- in the preparation of DMEM (dulbecco′s modified eagle′s medium)/F-12 media to culture human epidermal growth factor receptor 2 (HER2) cells derived from MMTV-HER2 transgenic mouse mammary tumors
- to administer the cultures to study its effect on the endogenous phosphatidyl ethanolamine pool and autophagy process
| | Biochem/physiol Actions | Ethanolamine hydrochloride is utilized as a carbon and nitrogen source by bacteria that differs phylogenetically. It exists as phosphotidylethanolamine in the bacterial and mammalian cell membrane. Ethanolamine-ammonia lyase is responsible for the degradation of ethanolamine into acetaldehyde and ammonia. Ethanolamine is known to positively support lipid accumulation in photosynthetic organism model. | | Synthesis | General procedure for the synthesis of ethanolamine hydrochloride from 2-aminoethanol:
Reagents and reaction conditions: 36% concentrated hydrochloric acid, room temperature.
Operating steps:
1. 15.0 g of 2-aminoethanol was weighed and added to three reaction flasks.
2. 27.0 g of 36% concentrated hydrochloric acid was added dropwise at a constant rate through a dropping funnel under stirring conditions, and the reaction temperature was controlled to be no more than 40 °C. 3.
3. after completion of the dropwise addition, the reaction mixture was continued to be stirred for 20 minutes until the pH was about 2 and the reaction was terminated.
4. remove water from the reaction system by concentration under reduced pressure until a very small amount of water remains.
5. A small amount of toluene was added and the residual water was further removed by azeotropic distillation.
6. The reaction mixture was rapidly cooled to give 23.7 g of a slightly light brown solid product, ethanolamine hydrochloride (M-07), in 99% yield. | | Purification Methods | Recrystallise the salt from EtOH. It is deliquescent; store it dry. [Beilstein 4 IV 1406.] | | References | [1] Bulletin des Societes Chimiques Belges, 1984, vol. 93, # 10, p. 903 - 912
[2] Patent: CN105585607, 2016, A. Location in patent: Paragraph 0107; 0108; 0109; 0110
[3] Green Chemistry, 2016, vol. 18, # 9, p. 2834 - 2842
[4] Green Chemistry, 2017, vol. 19, # 13, p. 3152 - 3163 |
| | ETHANOLAMINE HYDROCHLORIDE Preparation Products And Raw materials |
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