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| | (4-Fluoro-3-nitrophenyl)acetic acid Basic information |
| | (4-Fluoro-3-nitrophenyl)acetic acid Chemical Properties |
| Boiling point | 391.2±27.0 °C(Predicted) | | density | 1.498±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 4.01±0.10(Predicted) | | Appearance | Light yellow to yellow Solid |
| | (4-Fluoro-3-nitrophenyl)acetic acid Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 3-nitro-4-fluorophenylacetic acid from 4-fluorophenylacetic acid: to a solution of concentrated sulfuric acid (20 mL) of 4-fluorophenylacetic acid (3 g, 19.46 mmol) was added drop by drop of nitric acid (0.913 mL, 20.44 mmol) at 0 °C, and the reaction was stirred for 1 hour. After completion of the reaction, the mixture was slowly poured into ice water and extracted with dichloromethane (DCM, 2 x 20 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated to dryness under reduced pressure to give 3-nitro-4-fluorophenylacetic acid (3.48 g, 90% yield). Mass spectrum (ESI) m/z: 198.1 ([M-H]+). | | References | [1] Patent: WO2013/134298, 2013, A1. Location in patent: Page/Page column 35
[2] Patent: WO2018/116107, 2018, A1. Location in patent: Page/Page column 25-26
[3] Patent: WO2004/89912, 2004, A1. Location in patent: Page 25
[4] Patent: US6218547, 2001, B1
[5] Patent: WO2013/131408, 2013, A1. Location in patent: Page/Page column 59 |
| | (4-Fluoro-3-nitrophenyl)acetic acid Preparation Products And Raw materials |
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