Uridine-5'-O-(3-thiotriphosphate) (sodium salt)

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Uridine-5'-O-(3-thiotriphosphate) (sodium salt) Basic information
Product Name:Uridine-5'-O-(3-thiotriphosphate) (sodium salt)
Synonyms:Uridine-5'-O-(3-thiotriphosphate) (sodium salt);Uridine-5'-O-(3-thiotriphosphate) (sodium salt)
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MW:0
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Mol File:Mol File
Uridine-5'-O-(3-thiotriphosphate) (sodium salt) Structure
Uridine-5'-O-(3-thiotriphosphate) (sodium salt) Chemical Properties
solubility Water: Soluble
Safety Information
MSDS Information
Uridine-5'-O-(3-thiotriphosphate) (sodium salt) Usage And Synthesis
DescriptionUridine-5'-O-(3-thiotriphosphate) (UTP-γ-S) is a hydrolysis-resistant derivative of UTP (Item No. 9003530) an agonist of the purinergic P2Y2 receptor.1 It induces inositol phosphate formation in 1321N1 astrocytoma cells expressing the human P2Y2 receptor (EC50 = 240 nM) and chloride secretion in primary nasal epithelial cells from patients with cystic fibrosis in a concentration-dependent manner. UTP-γ-S induces vasoconstriction in isolated human coronary arteries (EC50 = 25.1 µM).2WARNING This product is not for human or veterinary use.
References[1] EDUARDO R. LAZAROWSKI. Enzymatic synthesis of UTPγS, a potent hydrolysis resistant agonist of P2U-purinoceptors[J]. British Journal of Pharmacology, 1996, 117 1: 203-209. DOI: 10.1111/j.1476-5381.1996.tb15175.x
[2] M MALMSJÖ. Characterization of contractile P2 receptors in human coronary arteries by use of the stable pyrimidines uridine 5’-O-thiodiphosphate and uridine 5’-O-3-thiotriphosphate.[J]. Journal of Pharmacology and Experimental Therapeutics, 2000, 293 3: 755-760.
Uridine-5'-O-(3-thiotriphosphate) (sodium salt) Preparation Products And Raw materials
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