- Cytochalasin E
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- $665.00 / 5mg
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2025-07-21
- CAS:36011-19-5
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | CYTOCHALASIN E Basic information |
| Product Name: | CYTOCHALASIN E | | Synonyms: | (7S,13E,16S,18R,19E)-6,7-Epoxy-18-hydroxy-16,18-dimethyl-10-phenyl-21,23-dioxa[13]cytochalasa-13,19-diene-1,17,22-trione;[7β,13E,16S,18R,19E]-6,7-Epoxy-18-hydroxy-16,18-dimethyl-10-phenyl-21,23-dioxa[13]cytochalasa-13,19-diene-1,17,22-trione;(7s,13e,16s,18r,19e)-18-dimethyl-10-phenyl;21,23-dioxa(13)cytochalasa-13,19-diene-1,17,22-trione,6,7-epoxy-18-hydroxy-16,;6,7-epoxy-10-phenyl-5,6,16,18-tetramethyl-21,23-dioxa-[13]cytochalas-13,19-die;CYTOCHALASIN 3;CYTOCHALASIN E;CYTOCHALASIN E, ASPERGILLUS CLAVATUS | | CAS: | 36011-19-5 | | MF: | C28H33NO7 | | MW: | 495.56 | | EINECS: | 252-835-7 | | Product Categories: | antibiotic;Actin Inhibitors and ProbesCell Signaling and Neuroscience;Cell Signaling and Neuroscience;Cytoskeleton and Extracellular Matrix;Mold;Toxins and Venoms | | Mol File: | 36011-19-5.mol |  |
| | CYTOCHALASIN E Chemical Properties |
| Melting point | 206 °C | | Boiling point | 587.59°C (rough estimate) | | density | 1.2415 (rough estimate) | | refractive index | 1.6290 (estimate) | | storage temp. | -20°C | | solubility | DMF: 11 mg/ml; DMF:PBS (pH7.2) (1:30): 0.03 mg/ml; DMSO: 10 mg/ml; Ethanol: 2 mg/ml | | form | White solid. | | pka | 11.22±0.70(Predicted) | | color | White to off-white | | BRN | 1096975 | | LogP | 1.920 (est) |
| | CYTOCHALASIN E Usage And Synthesis |
| Description | The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin E is an epoxide-containing analog of cytochalasin B which potently and selectively inhibits the growth of endothelial cells (IC50 < 1 nM), impairing angiogenesis and tumor growth. This cytochalasin does not inhibit glucose transport or HIV-1 protease activity. | | Chemical Properties | white powder | | Uses | Cytochalasin E is one of a family of potent mycotoxins produced by a range of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, resulting in pronounced morphogenic changes in animals and plants. Despite the common mode of action, there is evidence that individual members display diverse selectivity. Specifically, cytochalasin E acts as an angiogenesis inhibitor and, unlike other cytochalasins, does not inhibit glucose transport. | | Uses | Cytochalasin E is a fungal metabolite which has been shown to exhibit antimicrobial and antibacterial effects. Cytochalasin E is a microfilament inhibitor enhancing the low-affinity Fc epsilon receptor (CD23) expression. | | Uses | Cytochalasin E has been used as:
- a toxin to study its effects on avocado plants
- a component of the incubating medium in feline junctional adhesion molecule 1 (fJAM-1) expression assay
- an inhibitor of actin polymerization to study its effects on mitochondria uptake by mice endothelial cells
| | Definition | ChEBI: A natural product found in Arthrinium sacchari. | | Biochem/physiol Actions | Cytochalasin E is an epoxide that exhibits anti-proliferative activity in endothelial cells in vitro. It also participates in inhibiting tumor growth and angiogenesis in vivo. Cytochalasin E also possesses antimicrobial and antiviral properties. | | References | [1] T UDAGAWA. Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth.[J]. Journal of Pharmacology and Experimental Therapeutics, 2000, 294 2: 421-427.
[2] R F KLETZIEN A S J F Perdue. Cytochalasin A and B. Inhibition of sugar uptake in cultured cells.[J]. The Journal of Biological Chemistry, 1972, 247 9: 2964-2966.
[3] J F GRIFFIN C Y J A L Rampal. Inhibition of glucose transport in human erythrocytes by cytochalasins: A model based on diffraction studies.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1982, 79 12: 3759-3763. DOI: 10.1073/pnas.79.12.3759
[4] Y.B. LOMBARDO . Long-term administration of a sucrose-rich diet to normal rats: Relationship between metabolic and hormonal profiles and morphological changes in the endocrine pancreas[J]. Metabolism: clinical and experimental, 1996, 45 12: Pages 1527-1532. DOI: 10.1016/s0026-0495(96)90183-3 |
| | CYTOCHALASIN E Preparation Products And Raw materials |
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