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| | 4-(3-BROMO-PHENYL)-THIAZOL-2-YLAMINE Basic information | | Application |
| Product Name: | 4-(3-BROMO-PHENYL)-THIAZOL-2-YLAMINE | | Synonyms: | BUTTPARK 41\03-41;AURORA 22596;ART-CHEM-BB B000319;4-(3-BROMO-PHENYL)-THIAZOL-2-YLAMINE;4-(3-BROMOPHENYL)-1,3-THIAZOL-2-AMINE;4-(3-BROMOPHENYL)-1,3-THIAZOLE-2-YLAMINE;AKOS B000319;AKOS BBS-00008008 | | CAS: | 105512-81-0 | | MF: | C9H7BrN2S | | MW: | 255.13 | | EINECS: | | | Product Categories: | | | Mol File: | 105512-81-0.mol |  |
| | 4-(3-BROMO-PHENYL)-THIAZOL-2-YLAMINE Chemical Properties |
| Melting point | 130-131°C | | Boiling point | 398.8±17.0 °C(Predicted) | | density | 1.636 | | storage temp. | Storage temp. 2-8°C | | pka | 4.14±0.10(Predicted) | | Appearance | White to yellow Solid | | CAS DataBase Reference | 105512-81-0(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36/37/39 | | HazardClass | IRRITANT | | HS Code | 2934100090 |
| | 4-(3-BROMO-PHENYL)-THIAZOL-2-YLAMINE Usage And Synthesis |
| Application | 2-Aminothiazole ring derivatives are an important group of heterocyclic compounds, and 2-amino-4-(3-bromophenyl)thiazole can be used as a pharmaceutical synthesis intermediate. This structure is widely used in the fields of pesticides and pharmaceuticals. Many natural products or small molecule drugs with anti-inflammatory, antitumor, antiviral, and sedative effects contain the 2-aminothiazole ring, making it one of the most frequently constructed functional groups in green drug research in recent years. | | Synthesis | 2-Amino-4-(3-bromophenyl)thiazole was prepared as follows: in a 25mL reaction vial, 3mL water, 30L cyclodextrin, 0.50mmol1-bromo-3-ethylbenzene, 1.50mmolNBS and 0.05mmolAIBN were added sequentially and the reaction was carried out at 60C for 4h. After the reaction was completed, it was cooled and then 1.50mmol sodium bicarbonate and 0.50mmol thiourea were added sequentially. mmol thiourea, and reacted at 80 for 1h, at the end of the reaction, ethyl acetate was added, saturated saline was added to extract, the organic phase was concentrated, and column chromatography yielded 97 mg of white solid 2-amino-4-(3-bromophenyl)thiazole, the yield was 76%. |
| | 4-(3-BROMO-PHENYL)-THIAZOL-2-YLAMINE Preparation Products And Raw materials |
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