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4-(3-Bromo-phenyl)-thiazol-2-ylamine

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4-(3-Bromo-phenyl)-thiazol-2-ylamine Basic information
Application
Product Name:4-(3-Bromo-phenyl)-thiazol-2-ylamine
Synonyms:BUTTPARK 41\03-41;AURORA 22596;ART-CHEM-BB B000319;4-(3-BROMOPHENYL)-1,3-THIAZOL-2-AMINE;4-(3-BROMOPHENYL)-1,3-THIAZOLE-2-YLAMINE;AKOS B000319;AKOS BBS-00008008;4-(3-Bromo-phenyl)-thiazol- 2-ylamin
CAS:105512-81-0
MF:C9H7BrN2S
MW:255.13
EINECS:
Product Categories:
Mol File:105512-81-0.mol
4-(3-Bromo-phenyl)-thiazol-2-ylamine Structure
4-(3-Bromo-phenyl)-thiazol-2-ylamine Chemical Properties
Melting point 130-131°C
Boiling point 398.8±17.0 °C(Predicted)
density 1.636
storage temp. Storage temp. 2-8°C
pka4.14±0.10(Predicted)
AppearanceWhite to yellow Solid
CAS DataBase Reference105512-81-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36/37/39
HazardClass IRRITANT
HS Code 2934100090
MSDS Information
4-(3-Bromo-phenyl)-thiazol-2-ylamine Usage And Synthesis
Application2-Aminothiazole ring derivatives are an important group of heterocyclic compounds, and 2-amino-4-(3-bromophenyl)thiazole can be used as a pharmaceutical synthesis intermediate. This structure is widely used in the fields of pesticides and pharmaceuticals. Many natural products or small molecule drugs with anti-inflammatory, antitumor, antiviral, and sedative effects contain the 2-aminothiazole ring, making it one of the most frequently constructed functional groups in green drug research in recent years.
Synthesis2-Amino-4-(3-bromophenyl)thiazole was prepared as follows: in a 25mL reaction vial, 3mL water, 30L cyclodextrin, 0.50mmol1-bromo-3-ethylbenzene, 1.50mmolNBS and 0.05mmolAIBN were added sequentially and the reaction was carried out at 60C for 4h. After the reaction was completed, it was cooled and then 1.50mmol sodium bicarbonate and 0.50mmol thiourea were added sequentially. mmol thiourea, and reacted at 80 for 1h, at the end of the reaction, ethyl acetate was added, saturated saline was added to extract, the organic phase was concentrated, and column chromatography yielded 97 mg of white solid 2-amino-4-(3-bromophenyl)thiazole, the yield was 76%.
4-(3-Bromo-phenyl)-thiazol-2-ylamine Preparation Products And Raw materials
Raw materials3-Bromophenacyl bromide-->3-Bromostyrene-->1-Bromo-3-ethylbenzene-->Potassium thiocyanate-->Carbamimidothioic acid-->3'-Bromoacetophenone
Tag:4-(3-Bromo-phenyl)-thiazol-2-ylamine(105512-81-0) Related Product Information
4-(2-Bromo-phenyl)-thiazol-2-ylamine 4-(4-BROMO-PHENYL)-THIAZOL-2-YLAMINE Ethyl 2-amino-4-(4-bromophenyl)thiazole-5-carboxylate 4-(3-Bromo-4-fluorophenyl)thiazol-2-ylamine 4-(3-Bromo-4-methoxyphenyl)-1,3-thiazol-2-amine 4-(3-Bromo-phenyl)-thiazol-2-ylamine N-[4-(3-Bromo-phenyl)-thiazol-2-yl]-2-chloro-acetamide 4-(2-Bromo-phenyl)-thiazol-2-ylamine (4-(3-Bromophenyl)(2,5-thiazolyl))(4-(trifluoromethoxy)phenyl)amine [4-(3-Bromo-phenyl)-thiazol-2-yl]-hydrazine N-[4-(3-Bromo-phenyl)-thiazol-2-yl]-guanidine 2-Amino-4-(5-bromo-2-methoxyphenyl)-5-thiazolecarboxylic acid ethyl ester 5-(((4-(3-Bromophenyl)(2,5-thiazolyl))amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (4-(3-Bromophenyl)(2,5-thiazolyl))(2-chlorophenyl)amine, hydrobromide N-[4-(3-Bromo-4-methoxyphenyl)-1,3-thiazol-2-yl]-1-benzofuran-2-carboxamide 2-Amino-4-(3-bromo-4-methoxyphenyl)-5-thiazolecarboxylic acid ethyl ester AKOS BBS-00008233 BUTTPARK 16\06-62