14,15-Leukotriene d4 manufacturers
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| | 14,15-Leukotriene d4 Basic information |
| Product Name: | 14,15-Leukotriene d4 | | Synonyms: | Eoxin D4;Glycine, S-[(1R,2E,4E,6Z,9Z)-13-carboxy-1-[(1S)-1-hydroxyhexyl]-2,4,6,9-tridecatetraen-1-yl]-L-cysteinyl-;14,15-Leukotriene d4 | | CAS: | 75290-64-1 | | MF: | C25H40N2O6S | | MW: | 496.66 | | EINECS: | | | Product Categories: | | | Mol File: | 75290-64-1.mol |  |
| | 14,15-Leukotriene d4 Chemical Properties |
| Boiling point | 786.4±60.0 °C(Predicted) | | density | 1.162±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): >100 μg/ml | | pka | 3.03±0.10(Predicted) |
| | 14,15-Leukotriene d4 Usage And Synthesis |
| Description | 14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTD4 is classified as an eoxin (EXD4), because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTD4 as well. Little is known about the physiological actions of 14,15-LTD4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs. However, in an in vitro permeability assay, 14,15-LTD4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs, resulting in plasma leakage, a hallmark of inflammation. | | Uses | Eoxin D4 is synthesized via the 15-lipoxygenase-1 pathway in human eosinophils. Eoxins are proinflammatory arachidonic acid metabolites produced by mast cells. | | Definition | ChEBI: Eoxin D4 is a leukotriene that is the 14R-(S-cysteinylglycyl),15S-hydroxy derivative of (5Z,8Z,10E,12E)-icosa-7,9,11,14-tetraenoic acid. It has a role as a metabolite. It is a leukotriene and an eoxin. It is functionally related to a (5Z,8Z,10E,12E)-icosatetraenoic acid. |
| | 14,15-Leukotriene d4 Preparation Products And Raw materials |
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