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4-(5-Ethoxy-3-pyridinyl)-N-methyl-(3E)-3-buten-1-amine difumarate manufacturers
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| | 4-(5-Ethoxy-3-pyridinyl)-N-methyl-(3E)-3-buten-1-amine difumarate Basic information |
| | 4-(5-Ethoxy-3-pyridinyl)-N-methyl-(3E)-3-buten-1-amine difumarate Chemical Properties |
| Melting point | 123-125°C | | storage temp. | Desiccate at RT | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Off-White | | Water Solubility | Soluble to 100 mM in water |
| | 4-(5-Ethoxy-3-pyridinyl)-N-methyl-(3E)-3-buten-1-amine difumarate Usage And Synthesis |
| Uses | TC 2559 Fumarate is a partial agonist for AChR α4β2. | | Biological Activity | Subtype-selective partial agonist for α 4 β 2 nicotinic acetylcholine receptors (EC 50 values are 0.18, 12.5, 14.0, > 30, > 100 and > 100 μ M for α 4 β 2, α 4 β 4, α 2 β 4, α 3 β 4, α 3 β 2 and α 7 receptor subtypes respectively). Displays selectivity for ( α 4) 2 ( β 2) 3 receptor stoichiometry and enhanced CNS-PNS selectivity ratio. Attenuates scopolamine-induced cognitive deficits in a step-through passive avoidance task. |
| | 4-(5-Ethoxy-3-pyridinyl)-N-methyl-(3E)-3-buten-1-amine difumarate Preparation Products And Raw materials |
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