- 4E1rcat
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- $47.00
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2026-07-27
- CAS:328998-25-0
- Purity: 99.36%
- Supply Ability: 10g
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| | 4E1RCat Basic information |
| Product Name: | 4E1RCat | | Synonyms: | 4E1RCat;Benzoic acid, 4-[2,3-dihydro-3-[[5-(4-nitrophenyl)-2-furanyl]Methylene]-2-oxo-5-phenyl-1H-pyrrol-1-yl]-;4-[(3E)-3-[[5-(4-Nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl]benzoic acid;4-[(3E)-3-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenylpyrrol-1-yl]benzoic acid;4-[2,3-Dihydro-3-[[5-(4-nitrophenyl)-2-furanyl]methylene]-2-oxo-5-phenyl-1H-pyrrol-1-yl]benzoic acid;CS-1228;inhibit,Inhibitor,4E-1rcat,4E1rcat,Eukaryotic Initiation Factor (eIF),Autophagy;4-(3-((5-(4-Nitrophenyl)furan-2-yl)methylene)-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl)benzoic acid | | CAS: | 328998-25-0 | | MF: | C28H18N2O6 | | MW: | 478.45 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 328998-25-0.mol |  |
| | 4E1RCat Chemical Properties |
| Boiling point | 764.8±60.0 °C(Predicted) | | density | 1.423±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: ≥5mg/mL | | pka | 4.23±0.10(Predicted) | | form | powder | | color | brown to dark brown | | InChI | 1S/C28H18N2O6/c31-27-21(16-24-14-15-26(36-24)19-6-12-23(13-7-19)30(34)35)17-25(18-4-2-1-3-5-18)29(27)22-10-8-20(9-11-22)28(32)33/h1-17H,(H,32,33)/b21-16+ | | InChIKey | BBQRBOIMSKMFFO-LTGZKZEYSA-N | | SMILES | OC(=O)c1ccc(cc1)N2C(=O)\C(=C\c3ccc(o3)-c4ccc(cc4)[N+]([O-])=O)C=C2c5ccccc5 |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | 4E1RCat Usage And Synthesis |
| Description | 4E1RCat is an inhibitor of the eIF4F translation initiation complex that blocks eIF4E:eIF4G and eIF4E:4E-BP1 interactions. It has been shown to prevent the assembly of the eIF4F complex and to inhibit cap-dependent translation with an IC50 value of ~4 μM. 4E1RCat was shown to reverse tumor chemoresistance in a mouse model of lymphoma by sensitizing cells to the proapoptotic action of DNA damage. | | Uses | 4E1RCat was used to inhibit new protein synthesis in transformed primary chicken embryo fibroblasts. | | Biochem/physiol Actions | 4E1RCat ilnhibits the eIF4F translation initiation complex by binding to IF4E b and inhibiting the interaction between IF4E:eIF4G (IC50 = 3.2 μM). In in vitro translation experiments using MDA-MB-231 cells, 4E1RCat dose dependently inhibited cap-dependent translation, led to a decrease in polysome and 80S ribosomal subunits and reduced levels of the eIF4F-dependant proteins Mcl-1 and c-Myc. | | in vivo | 4E1RCat (15 mg/kg, i.p.) affacts chemosensitivity of Pten+/-Eμ-Myc tumors in mice. 4E1RCat (15 mg/kg, i.p.) sensitizes Pten+/-Eμ-Myc and Tsc2+/-Eμ-Myc lymphomas to the cytotoxic effects of doxorubicin (Dxr), and 4E1RCat targets translation in mice[1]. | | IC 50 | eIF4 | | References | [1] REGINA CENCIC. Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 3: 1046-1051. DOI: 10.1073/pnas.1011477108 |
| | 4E1RCat Preparation Products And Raw materials |
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