- 4EGI-1
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- $37.00
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2026-07-27
- CAS:315706-13-9
- Purity: 99.59%
- Supply Ability: 10g
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| Product Name: | 4EGI-1 | | Synonyms: | 4EGI-1;α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid;eIF4E/eIF4G Interaction Inhibitor, 4EGI-1;4EGI-1, >=98%;alpha-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitrobenzenepropanoic acid;2-((4-(3,4-Dichlorophenyl)thiazol-2(3H)-ylidene)hydrazono)-3-(2-nitrophenyl)propanoic acid;4EGI-1/4EGI1;2-[[4-(3,4-dichlorophenyl)-4,5-dihydro-1,3-thiazol-2-yl]hydrazinylidene]-3-[2-(dihydroxyamino)phenyl]propanoic acid | | CAS: | 315706-13-9 | | MF: | C18H12Cl2N4O4S | | MW: | 451.28 | | EINECS: | 2017-001-1 | | Product Categories: | Inhibitors | | Mol File: | 315706-13-9.mol |  |
| | 4EGI-1 Chemical Properties |
| Boiling point | 668.9±65.0 °C(Predicted) | | density | 1.58±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≥22.56 mg/mL in DMSO | | form | Brown solid. | | pka | 0.89±0.41(Predicted) | | color | Light yellow to khaki | | InChI | 1S/C18H12Cl2N4O4S/c19-12-6-5-10(7-13(12)20)15-9-29-18(21-15)23-22-14(17(25)26)8-11-3-1-2-4-16(11)24(27)28/h1-7,9H,8H2,(H,21,23)(H,25,26)/b22-14+ | | InChIKey | KFRKRECSIYXARE-HYARGMPZSA-N |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 4EGI-1 Usage And Synthesis |
| Description | In eukaryotes, a set of initiation factors (eIFs) interact with ribosomal subunits to initiate mRNA translation. A major step in initiation is the assembly of a large multiprotein complex that includes the cap-binding protein eIF4E and the multidomain adaptor protein eIF4G. 4EGI-1 is an inhibitor of the initiation of translation that blocks the interaction of eIF4G with eIF4E (KD = 25 μM). It directly binds eIF4E, competitively inhibiting an association with eIF4G that is necessary for cap-dependent translation. 4EGI-1 prevents the expression of oncogenic proteins in mammalian cancer cells, leading to apoptosis. Research with this inhibitor supports a role for normal eIF4E/eIF4G interaction in memory consolidation and excess interaction in autism spectrum disorders. 4EGI-1 also blocks translation in some viruses that do not require eIF4E or a cap structure for initiation. | | Uses | eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 is amplifies TRAIL-induced apoptosis via down-regulation of FLIPS/Land induction of DR5. | | Definition | ChEBI: 4EGI-1 is a dichlorobenzene, a member of 1,3-thiazoles, a C-nitro compound, a monocarboxylic acid and a hydrazone. | | in vivo | 4EGI-1 (75 mg/kg, i.p.) inhibits breast cancer stem cells (CSC) tumor growth and tumorangiogenesis in vivo[2]. 4EGI-1 (75 mg/kg, i.p.) shows inhibitory effect on the tumor volume and weight in mice bearing U87 cells[3]. | | IC 50 | eIF4 | | storage | Store at -20°C | | references | [1] moerke n j, aktas h, chen h, et al. small-molecule inhibition of the interaction between the translation initiation factors eif4e and eif4g. cell, 2007, 128(2): 257-267. |
| | 4EGI-1 Preparation Products And Raw materials |
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