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(alphaR)-3,5-Difluoro-alpha-hydroxybenzeneacetic acid 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide

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(alphaR)-3,5-Difluoro-alpha-hydroxybenzeneacetic acid 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide Basic information
Product Name:(alphaR)-3,5-Difluoro-alpha-hydroxybenzeneacetic acid 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide
Synonyms:(alphaR)-3,5-Difluoro-alpha-hydroxybenzeneacetic acid 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide;EMD638683 (R-Form);Benzeneacetic acid, 3,5-difluoro-α-hydroxy-, 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide, (αR)-;EMD638683 R Form,EMD638683 RForm,EMD-638683 R-Form
CAS:1184940-47-3
MF:C18H18F2N2O4
MW:364.34
EINECS:
Product Categories:
Mol File:1184940-47-3.mol
(alphaR)-3,5-Difluoro-alpha-hydroxybenzeneacetic acid 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide Structure
(alphaR)-3,5-Difluoro-alpha-hydroxybenzeneacetic acid 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide Chemical Properties
Boiling point 657.6±55.0 °C(Predicted)
density 1.363
form Solid
pka8.68±0.25(Predicted)
color Off-white to pink
Safety Information
MSDS Information
(alphaR)-3,5-Difluoro-alpha-hydroxybenzeneacetic acid 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide Usage And Synthesis
UsesEMD638683 R-Form is the R-form of EMD638683. EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM.
References[1] Ackermann TF, et al. EMD638683, a novel SGK inhibitor with antihypertensive potency. Cell Physiol Biochem. 2011;28(1):137-46. DOI:10.1159/000331722
(alphaR)-3,5-Difluoro-alpha-hydroxybenzeneacetic acid 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide Preparation Products And Raw materials
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