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Energy Chemical |
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400-0056266 |
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| | 3-Bromo-2-chlorophenol Basic information | | Uses |
| | 3-Bromo-2-chlorophenol Chemical Properties |
| Melting point | 60 °C | | Boiling point | 246.1±20.0 °C(Predicted) | | density | 1.788±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | pka | 7.53±0.10(Predicted) | | Appearance | White to light brown Solid | | InChI | InChI=1S/C6H4BrClO/c7-4-2-1-3-5(9)6(4)8/h1-3,9H | | InChIKey | DUKKNDLIWRYBCT-UHFFFAOYSA-N | | SMILES | C1(O)=CC=CC(Br)=C1Cl |
| | 3-Bromo-2-chlorophenol Usage And Synthesis |
| Uses | 3-Bromo-2-chlorophenol is a pharmaceutical intermediate that has been reported in the literature to be used in the preparation of PD-1/PD-L1 inhibitors as well as dual inhibitors of D2 and DAT receptors. | | Synthesis |
326.4 g (2.04 moles) of bromine is added dropwise in 6 hours with vigorous stirring, within a temperature range of between 20° and 45° C., to a mixture of 257.2 g (2 moles) of 2-chlorophenol, 1.0 g of zinc chloride and 1.0 g of diphenyl sulfide. After adding 70 ml of bromine, the temperature rises to 35° C. To avoid crystallization, the reaction mixture is afterwardheated to 40° C., Afterward, 20 ml of bromine is added dropwise. The remaining bromine is finally added at 45° C. After the addition of bromine is complete, stirring is maintained for 30 minutes at 50° C., and subsequently, the reaction product is freed at 60° C. under reduced pressure from dissolved hydrogen bromide to leave 414.5 g (99.8% of theory) of chlorobromophenol(3-Bromo-2-chlorophenol).
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| | 3-Bromo-2-chlorophenol Preparation Products And Raw materials |
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