7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]-

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7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- Suppliers list
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7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- manufacturers
7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- Basic information
Product Name:7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]-
Synonyms:N-Methyl-N-[(3R,4R)-4-methyl-1-(phenylmethyl)-3-piperidinyl]-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine;7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]-;Tofacitinib-13;Tofacitinib impurity 9/N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine;N-Des(-3'-oxopropanenitrile)-N-(methyl)benzene Tofacitinib N-Hydrosulfonylmethylbenzene;7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-methyl-N-[(3R,4R)-4-me...;Azilsartan medoxomil impurity341;Tofatinib Impurity 4
CAS:923036-30-0
MF:C27H31N5O2S
MW:489.63
EINECS:
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Mol File:923036-30-0.mol
7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- Structure
7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- Chemical Properties
Melting point 180-183℃
Boiling point 655.2±65.0 °C(Predicted)
density 1.27±0.1 g/cm3(Predicted)
storage temp. 2-8°C
pka9.02±0.10(Predicted)
AppearanceWhite to off-white Solid
Safety Information
MSDS Information
7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- Usage And Synthesis
UsesA useful intermediate for the formal asymmetric synthesis of (+)-Tofacitinib. An impurity of Tofacitinib(C781351).
Synthesis
(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine

477600-70-7

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

479633-63-1

7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]-

923036-30-0

(3R,4R)-1-benzyl-4-methyl-3-methylamino-piperidine (4.3 g, 19.7 mmol, 1.0 eq.) was dissolved in 180 mL of water, followed by the addition of 4-chloro-7-toluenesulfonyl-7H-pyrrolo[2,3-D]pyrimidine (12.3 g, 39.2 mmol, 2.0 eq.) and potassium carbonate (16.6 g, 119 mmol. 6.0 eq.). The reaction mixture was stirred at 100 °C for 16 h and then cooled to room temperature. After completion of the reaction, the reaction was extracted three times with ethyl acetate (500 mL), the organic phases were combined and washed sequentially with water and brine. The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography (eluent: ethyl acetate/petroleum ether=1:1) to afford N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7-toluenesulfonyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (8.6 g, 90% yield) as a pale yellow solid.

References[1] Patent: CN103896946, 2018, B. Location in patent: Paragraph 0084; 0085; 0086
[2] Journal of Medicinal Chemistry, 2008, vol. 51, # 24, p. 8012 - 8018
7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- Preparation Products And Raw materials
Raw materials(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine-->4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine-->Potassium carbonate
Tag:7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]-(923036-30-0) Related Product Information
4-(Hydroxyamino)-4-oxobutanoic acid 3-Amino-4-methylpyridine N-((3S,4S)-1-benzyl-4-Methylpiperidin-3-yl)-N-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine Methyl (1-benzyl-4-Methylpiperidin-3-yl)carbaMate 13-Deoxyepirubicin 3-((3R,4S)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanenitrile 3-METHOXYCARBONYLAMINO-4-METHYLPYRIDINE 1-[2-(2-methoxyphenoxy)ethylamino]-3-(9-methylcarbazol-4-yl)oxypropan-2-ol:hydrochloride Methyl (4-Methylpiperidin-3-yl)carbaMate 3-((3S,4R)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanenitrile 3-PiperidinaMine, 1-acetyl-N,4-diMethyl-N-1H-pyrrolo[2,3-d]pyriMidin-4-yl-, (3R,4R)- (9CI) 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE 3-bis(4-Methylbenzoyloxy)succinate) 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine