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| | TAS-102 Basic information |
| Product Name: | TAS-102 | | Synonyms: | TAS-102;Tipiracil hydrochloride-trifluridine mixt.;TRIFLURIDINE-TIPIRACIL HYDROCHLORIDE MIXTURE;TAS-102(Tipiracil hydrochloride-trifluridine mixt);Trifluridine-tipiracil hydrochloride mixt.;TAS-102(TIPIRACIL, TRIFLURIDINE);TAS-102 (LONSURF);TAS102; TAS 102 | | CAS: | 733030-01-8 | | MF: | C19H23Cl2F3N6O7 | | MW: | 575.32 | | EINECS: | | | Product Categories: | | | Mol File: | 733030-01-8.mol |  |
| | TAS-102 Chemical Properties |
| Melting point | 170-172°C | | storage temp. | Hygroscopic, Refrigerator, under inert atmosphere | | solubility | DMSO (Slightly, Heated, Sonicated), Methanol (Slightly) | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Carc. 2
Muta. 2
Repr. 2 |
| | TAS-102 Usage And Synthesis |
| Uses | TAS 102 (Tipiracil-trifluridine) is a thymidine phosphorylase inhibitor used in chemotherapy treatment of advanced/recurring colorectal cancer. | | Biological Activity | Anti cancer, Anti angiogenic | | in vivo | Trifluridine/tipiracil hydrochloride mixture (150 mg/kg/day; p.o.; twice a day for 14 days) prevents body weight loss and reduces the relative tumor volume in colorectal cancer and gastric cancer mice models[2]. | Animal Model: | Male nude mice bearing KM12C, KM12C/5-FU, DLD-1, DLD-1/5-FU, and SC-2 cells[2] | | Dosage: | 150 mg/kg/day | | Administration: | p.o.; twice a day for 14 days | | Result: | Prevented body weight loss and reduced the relative tumor volume in colorectal cancer and gastric cancer mice models. |
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| | TAS-102 Preparation Products And Raw materials |
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