- RBC8
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- $93.00 / 5mg
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2025-10-26
- CAS:361185-42-4
- Min. Order:
- Purity: 99.81%
- Supply Ability: 10g
- RBC8
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- $1.00 / 1g
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2024-10-22
- CAS:361185-42-4
- Min. Order: 1g
- Purity: MIn98% HPLC/LC
- Supply Ability: 100KGS
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| | 6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile Basic information |
| Product Name: | 6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile | | Synonyms: | 6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile;RBC8;CS-2174;CS-2130;RBC8, >98%;6-amino-4-(2,4-dimethoxyphenyl)-3-(naphthalen-2-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile;
6-Amino-4-(2,5-dimethoxyphenyl)-3-(naphthalen-2-yl)-1,4-dihydropyrano[2,3-c ]pyrazole-5-carbonitrile;RBC-8;RBC 8 | | CAS: | 361185-42-4 | | MF: | C25H20N4O3 | | MW: | 424.45 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 361185-42-4.mol | ![6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile Structure](CAS/20180703/GIF/361185-42-4.gif) |
| | 6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile Chemical Properties |
| Boiling point | 701.9±60.0 °C(Predicted) | | density | 1.40±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | solid | | pka | 10.51±0.70(Predicted) | | color | White |
| | 6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile Usage And Synthesis |
| Uses | RBC8 is a RalA and RalB inhibitor of the GTPase enzyme, inhibiting binding of Ral to TaLBP1. Used in the treatment and suppression of xenograft tumors, shown in mice. | | Biological Activity | rbc8 inhibit ral gtpase with ic50 values of 3.5 μm and 3.4 μm in ral-dependent lines h2122 and h358 [1].rala and b are ras-like gtpases. they are important drivers of metastasis and tumor growth [1].rbc8 reduced the activation of rala in living cells. ral is required for spreading murine embryonic fibroblasts (mefs) and lipid raft exocytosis on fibronectin-coated cover slips. in these cells, the spreading of wt mefs was inhibited by the depletion of rala via sirna, whereas caveolin deficient (cav1-/-) mefs were resistant to rala depletion. treatment with rbc8 inhibited only the cell spreading in the wt mefs, it did not inhibited the cell spreading in cav1-/- mefs. a ral pull-down assay showed that rbc8 inhibited the activation of both rala and ralb in both the h2122 and h358 cell lines. in h2122 and h358 cells with ral knockdown by sirna, treatment with rbc8 did not show further inhibition of colony formation [1].in nude mice inoculated with h2122 human lung cancer cells subcutaneously, treatment with rbc8 at 50 mg/kg/d for 21 days (except weekends) intraperitoneally showed an inhibitory effect on tumor growth to a similar extent as dual knockdown of rala and b. h358 is a lung cancer line. in this cell line, similar results were yielded [1]. | | in vivo | RBC8 (50 mg/kg; i.p.; daily (except weekends); 21 days) inhibits tumor growth in nude mice inoculated with H2122 and H358 human lung cancer cells[2]. | Animal Model: | Female athymic nude mice (Ncr nu/nu; 5 - 6 weeks old, weight not specified) inoculated with H2122 or H358 human lung cancer cells[2]. | | Dosage: | 50 mg/kg (dissolved in DMSO) | | Administration: | Intraperitoneal injection, daily except weekends, for 21 days | | Result: | Inhibited the growth of xenograft tumors in nude mice inoculated with H2122 cells, and the effect was similar to that of dual knockdown of RalA and RalB.
Inhibited the growth of xenograft tumors in nude mice inoculated with H358 cells.
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| | storage | Store at -20°C | | references | [1]. yan c, liu d, li l, et al. discovery and characterization of small molecules that target the ral gtpase. nature, 2014, 515(7527): 443-447. |
| | 6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile Preparation Products And Raw materials |
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