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Alfa Aesar |
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400-6106006 |
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Ark Pharm, Inc. |
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847-367-3680 |
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| | 3-Hydroxy-4-pyridinecarboxylic acid Basic information |
| Product Name: | 3-Hydroxy-4-pyridinecarboxylic acid | | Synonyms: | 3-HYDROXY PYRIDINE-4-CARBOXYLIC ACID;3-Hydroxy-4-pyridinecaboxylic acid;3-Hydroxy-4-pyridinecarboxylic acid ,97%;3-hydroxypyridin-4-carboxylic acid;3-Hydroxy-4-carboxypyridine;3-HydroxyisonicotinicAcid>;4-Pyridinecarboxylic acid, 3-hydroxy-;3-Hydroxyisonicotinicaci | | CAS: | 10128-71-9 | | MF: | C6H5NO3 | | MW: | 139.11 | | EINECS: | | | Product Categories: | Pyridines;pharmacetical | | Mol File: | 10128-71-9.mol |  |
| | 3-Hydroxy-4-pyridinecarboxylic acid Chemical Properties |
| Melting point | 317-319(dec.) | | Boiling point | 519.3±35.0 °C(Predicted) | | density | 1.485±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 0.51±0.10(Predicted) | | form | Solid | | color | Light yellow to Brown | | Water Solubility | Soluble in methanol. Slightly soluble in water. | | InChI | 1S/C6H5NO3/c8-5-3-7-2-1-4(5)6(9)10/h1-3,8H,(H,9,10) | | InChIKey | JEHGATQUCUYHJL-UHFFFAOYSA-N | | SMILES | OC(=O)c1ccncc1O | | CAS DataBase Reference | 10128-71-9(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36/37/39 | | WGK Germany | WGK 3 | | HazardClass | IRRITANT | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids |
| | 3-Hydroxy-4-pyridinecarboxylic acid Usage And Synthesis |
| Chemical Properties | Light yellow solid | | Uses | 3-Hydroxyisonicotinic Acid is used in the preparation of chelating agents for iron and aluminum. | | Synthesis | Step B: Synthesis of 3-hydroxyisonicotinic acid: 3-aminoisonicotinic acid (108.86 g, 788.13 mmol) was dissolved in water (1740 mL), followed by slow addition of sulfuric acid (84.020 mL, 1576.3 mmol). The resulting yellow slurry was cooled to below 10°C and a solution of sodium nitrite (60.359 g, 874.83 mmol) in water (510 mL) was added dropwise while maintaining the temperature below 10°C. Subsequently, the reaction mixture was heated to 80°C, at which point a large amount of precipitate generation was observed. After the suspension was cooled to 65°C, glacial acetic acid (88 mL, continuous decantation) and concentrated ammonium hydroxide (190 mL) were added sequentially to adjust the final pH to about 4.5. The precipitate was collected by vacuum filtration and washed with cold water. The solid was dried in air for 16 h to give the final free flowing granular 3-hydroxyisonicotinic acid (99.37 g, 91% yield). | | References | [1] Patent: US2007/49603, 2007, A1. Location in patent: Page/Page column 78; 30
[2] Patent: WO2008/24725, 2008, A1. Location in patent: Page/Page column 67
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 16, p. 6942 - 6990 |
| | 3-Hydroxy-4-pyridinecarboxylic acid Preparation Products And Raw materials |
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