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| | DG172 (dihydrochloride) Basic information |
| Product Name: | DG172 (dihydrochloride) | | Synonyms: | (αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitrile dihydrochloride;DG-172;DG172 (dihydrochloride);DG-172 (hydrochloride);DG172 2HCl;(Z)-2-(2-Bromophenyl)-3-(4-(4-methylpiperazin-1-yl)phenyl)acrylonitrile dihydrochloride;DG-172,DG172,DG172 dihydrochloride,PPAR,inhibit,DG 172,Inhibitor,Peroxisome proliferator-activated receptors;(αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitriledihydrochloride | | CAS: | 1361504-77-9 | | MF: | C20H21BrClN3 | | MW: | 418.76 | | EINECS: | | | Product Categories: | | | Mol File: | 1361504-77-9.mol |  |
| | DG172 (dihydrochloride) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | ≤20mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide | | form | crystalline solid | | color | Light yellow to yellow |
| | DG172 (dihydrochloride) Usage And Synthesis |
| Description | DG-172 is an orally available inverse agonist of PPARβ/δ (IC50 = 27 nM), down-regulating transcription of ANGPTL4 in mouse myoblasts (IC50 = 9.5 nM). It alters the differentiation of bone marrow cells, augmenting GM-CSF-induced development into subsets of mature and immature dendritic cells. Inverse agonists of PPARβ/δ, including DG-172, inhibit cancer cell invasion through suppression of ANGPTL4 expression. | | Uses | DG 172 Dihydrochloride is a potent peroxisome proliferator-activated receptor agonist and inhibit Angptl4 gene expression in mouse myoblasts. | | IC 50 | PPARβ/δ: 27 nM (IC50) | | references | [1]. lieber s, scheer f, meissner w, et al. (z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (dg172): an orally bioavailable pparβ/δ-selective ligand with inverse agonistic properties. j med chem. 2012 mar 22;55(6):2858-68.
[2]. lieber s, scheer f, finkernagel f, et al. the inverse agonist dg172 triggers a pparβ/δ-independent myeloid lineage shift and promotes gm-csf/il-4-induced dendritic cell differentiation. mol pharmacol. 2015 feb;87(2):162-73.
[3]. adhikary t, brandt dt, kaddatz k, et al. inverse pparβ/δ agonists suppress oncogenic signaling to the angptl4 gene and inhibit cancer cell invasion. oncogene. 2013 oct 31;32(44):5241-52. |
| | DG172 (dihydrochloride) Preparation Products And Raw materials |
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