| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
- IC87201
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- $84.00
-
2026-08-03
- CAS:866927-10-8
- Purity: 98.48%
- Supply Ability: 10g
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| | IC87201 Basic information |
| Product Name: | IC87201 | | Synonyms: | IC87201;2-[(1H-Benzotriazol-6-ylamino)methyl]-4,6-dichlorophenol;IC-87201
(IC87201;Phenol, 2-[(1H-benzotriazol-6-ylamino)methyl]-4,6-dichloro-;IC87201 >=98% (HPLC);2-(((1H-Benzo[d][1,2,3]triazol-6-yl)amino)methyl)-4,6-dichlorophenol;IC 87201,IC87201,IC-87201,inhibit,iGluR,Inhibitor,Ionotropic glutamate receptors;2-{[(1H-1,2,3-benzotriazol-6-yl)amino]methyl}-4,6-dichlorophenol | | CAS: | 866927-10-8 | | MF: | C13H10Cl2N4O | | MW: | 309.15 | | EINECS: | | | Product Categories: | API | | Mol File: | 866927-10-8.mol |  |
| | IC87201 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF:30.0(Max Conc. mg/mL);97.04(Max Conc. mM)
DMSO:29.0(Max Conc. mg/mL);93.81(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.81(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);3.23(Max Conc. mM) | | form | A solid | | color | Pink to red | | InChI | InChI=1S/C13H10Cl2N4O/c14-8-3-7(13(20)10(15)4-8)6-16-9-1-2-11-12(5-9)18-19-17-11/h1-5,16,20H,6H2,(H,17,18,19) | | InChIKey | QEHVTUCLCBXQIC-UHFFFAOYSA-N | | SMILES | C1(O)=C(Cl)C=C(Cl)C=C1CNC1C=C2NN=NC2=CC=1 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2 |
| | IC87201 Usage And Synthesis |
| Uses | IC 87201 (cas# 866927-10-8) is a useful research chemical.IC 87201 is a small molecule inhibitor. It inhibited the in vitro binding of nNOS with PSD95, without inhibiting nNOS catalytic activity. | | Biological Activity | IC87201 is a potent inhibitor of the nNOS/PSD-95 protein-protein interaction th at blocks NMDA-induced 3μ ,5μ -cyclic guanosine monophosphate (cGMP) production in hippocampal cultures. IC87201 exhibits analgesic properties in mice pain models. Contrary to NMDA receptor antagonists nNOS/PSD-95 protein-protein interaction inhibitors spared source memory, spatial memory, and motor function in rats. | | in vivo | IC87201 (1, 4 and 10 mg/kg, i.p.) does not produce impairment in either spatial working memory or source memory[2]. IC87201 (1 mg/kg) is effective in treating NMDA-induced thermal hyperalgesia in mice, with a corresponding peak plasma level of 55 ng/mL (or 0.2 μM)[3]. | | IC 50 | NMDA Receptor |
| | IC87201 Preparation Products And Raw materials |
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