N-(6-Chloropyridin-3-Yl)-3,4-Difluorobenzamide

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N-(6-Chloropyridin-3-Yl)-3,4-Difluorobenzamide manufacturers

  • ICA-27243
  • ICA-27243 pictures
  • $35.00
  • 2026-07-17
  • CAS:325457-89-4
  • Purity: 99.79%
  • Supply Ability: 10g
N-(6-Chloropyridin-3-Yl)-3,4-Difluorobenzamide Basic information
Product Name:N-(6-Chloropyridin-3-Yl)-3,4-Difluorobenzamide
Synonyms:N-(6-Chloropyridin-3-Yl)-3,4-Difluorobenzamide;ICA-027243;Benzamide, N-(6-chloro-3-pyridinyl)-3,4-difluoro-;antiepileptic,hyperpolarization,ICA-27243,opener,Inhibitor,KcsA,Potassium Channel,inhibit,KCNQ3,KCNQ2,ICA 27243,anticonvulsant,ICA27243;ICA-27243, 10 mM in DMSO
CAS:325457-89-4
MF:C12H7ClF2N2O
MW:268.65
EINECS:
Product Categories:
Mol File:325457-89-4.mol
N-(6-Chloropyridin-3-Yl)-3,4-Difluorobenzamide Structure
N-(6-Chloropyridin-3-Yl)-3,4-Difluorobenzamide Chemical Properties
Boiling point 318.5±42.0 °C(Predicted)
density 1.476±0.06 g/cm3(Predicted)
solubility DMSO: Soluble: =10 mg/ml
Ethanol: Sparingly Soluble: 1-10 mg/ml
form Solid
pka10.40±0.70(Predicted)
color White to off-white
Safety Information
MSDS Information
N-(6-Chloropyridin-3-Yl)-3,4-Difluorobenzamide Usage And Synthesis
UsesICA-27243 is a selective, potent and orally active KCNQ2/Q3 potassium channel opener with an EC50 of 0.38 μM. ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 has antiepileptic and anticonvulsant effects[1][2].
in vivo

ICA-27243 (1-100 mg/kg; oral administration; male CD-1 mice) has anticonvulsant activity (ED50 of 8.4 mg/kg) in the mouse maximal electroshock epilepsy model[1].

Animal Model:Male CD-1 mice with electroshock assay[1]
Dosage:1-100 mg/kg
Administration:Oral administration
Result:Produced a dose-dependent increase in the latency to hind limb extension, exhibiting an ED50 value of 8.4 mg/kg.
References[1] Wickenden AD, et al. N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. Mol Pharmacol. 2008 Mar;73(3):977-86. DOI:10.1124/mol.107.043216
[2] Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2(6):481-4. DOI:10.1021/ml200053x
[3] JOHN P. REDROBE  Alexander N N. Effects of neuronal Kv7 potassium channel activators on hyperactivity in a rodent model of mania[J]. Behavioural Brain Research, 2009, 198 2: Pages 481-485. DOI: 10.1016/j.bbr.2008.12.027
N-(6-Chloropyridin-3-Yl)-3,4-Difluorobenzamide Preparation Products And Raw materials
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