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| | ICA 069673 Basic information |
| Product Name: | ICA 069673 | | Synonyms: | ICA 069673;N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide;ICA069673;ICA-069673;Benzamide, N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-;ICA-069673 >=98% (HPLC);Potassium Channel,ICA 069673,ICA-069673,KcsA,inhibit,Inhibitor;N-(2-Chloropyrimidin-5-yl)-3,4-difluorobenzamide;ICA-069673, 10 mM in DMSO | | CAS: | 582323-16-8 | | MF: | C11H6ClF2N3O | | MW: | 269.63 | | EINECS: | | | Product Categories: | Selective KCNQ2/Q3 potassium channel opener. | | Mol File: | 582323-16-8.mol |  |
| | ICA 069673 Chemical Properties |
| Boiling point | 358.9±37.0 °C(Predicted) | | density | 1.539±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DNF:30.0(Max Conc. mg/mL);111.26(Max Conc. mM)
DMSO:36.24(Max Conc. mg/mL);134.4(Max Conc. mM)
Ethanol:30.25(Max Conc. mg/mL);112.18(Max Conc. mM) | | pka | 9.47±0.70(Predicted) | | form | Powder | | color | White to off-white | | InChI | 1S/C11H6ClF2N3O/c12-11-15-4-7(5-16-11)17-10(18)6-1-2-8(13)9(14)3-6/h1-5H,(H,17,18) | | InChIKey | IIBSHMFXVWTQSJ-UHFFFAOYSA-N | | SMILES | O=C(C1=CC=C(F)C(F)=C1)NC2=CN=C(Cl)N=C2 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | ICA 069673 Usage And Synthesis |
| Description | ICA 069673 is a heteromeric Kv7 channel activator. It is selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM, respectively) and also activates Kv7.4, Kv7.5, and heteromeric Kv7.4/7.5 channels in a dose-dependent manner. ICA 069673 has no activity against hERG, Nav1.5, and Kv7.1 cardiac ion channels (IC50s = >30 μM). Oral administration of ICA 069673 increases latency to first tonic-clonic seizure in the rat maximal electroshock and pentylentetrazol-induced seizure models (ED50s = 1.5 and <1 mg/kg, respectively). Formulations containing ICA 069673 are under clinical investigation for the treatment of epilepsy. | | Uses | ICA-069673 is a KCNQ2/Q3 potassium channel activator. ICA-069673 demonstrates greater selectivity for KV7.2/7.3 over KV7.3/KV7.5, with EC50s of 0.69 μM and 14.3 μM, respectively. ICA-069673 inhibits spontaneous phasic and nerve-evoked contractions in guinea pig detrusor smooth muscle (DSM). ICA-069673 also decreases the global intracellular Ca(2+) concentration in DSM cells[1][2]. | | storage | Room temperature | | References | [1] Provence A, et al. The Novel KV7.2/KV7.3 Channel Opener ICA-069673 Reveals Subtype-Specific Functional Roles in Guinea Pig Detrusor Smooth Muscle Excitability and Contractility. J Pharmacol Exp Ther. 2015 Sep;354(3):290-301. DOI:10.1124/jpet.115.225268 |
| | ICA 069673 Preparation Products And Raw materials |
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