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| | ISOPROPYLMAGNESIUM BROMIDE Basic information |
| | ISOPROPYLMAGNESIUM BROMIDE Chemical Properties |
| Melting point | 114-116℃ | | Boiling point | 148-154℃ | | density | 0.982 g/mL at 25 °C | | Fp | -17°C | | storage temp. | 2-8°C | | solubility | Miscible with tetrahydorfuran and diethyl ether. Immiscible with hydrocarbons. | | form | Solution | | color | Clear dark brown or dark gray | | Sensitive | Air & Moisture Sensitive | | InChI | InChI=1S/C3H7.BrH.Mg/c1-3-2;;/h3H,1-2H3;1H;/q;;+1/p-1 | | InChIKey | UCJIVFREPMUZDC-UHFFFAOYSA-M | | SMILES | C(C)(C)[Mg]Br | | EPA Substance Registry System | Magnesium, bromo(1-methylethyl)- (920-39-8) |
| Hazard Codes | F,C | | Risk Statements | 11-19-34-14/15-40-37-17-14 | | Safety Statements | 16-26-27-36/37/39-45-43-39-37-36 | | RIDADR | 3399 | | WGK Germany | 2 | | TSCA | TSCA listed | | HazardClass | 4.3 | | PackingGroup | I | | HS Code | 29319090 | | Storage Class | 4.3 - Hazardous materials which set free flammable gases upon contact with water | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Flam. Liq. 2
Skin Corr. 1B
Water-react 2 |
| | ISOPROPYLMAGNESIUM BROMIDE Usage And Synthesis |
| Chemical Properties | Clear dark brown or dark gray solution | | Uses | Isopropylmagnesium bromide is a Grignard reagent used in organic synthesis, especially for the introduction of iso-propyl group to carbonyl compounds. It is also used as a strong base in aprotic solvent. | | Uses | Grignard reagent in greener solvent, 2-methyltetrahydrofuran (2-MeTHF)
2-Methyltetrahydrofuran (2-MeTHF): A Biomass-Derived Solvent with Broad Application in Organic Chemistry | | General Description | This product, 2.9 M in 2-methyltetrahydrofuran aligns with Safer Solvents and Auxiliaries, Use of Renewable Feedstocks and Inherently Safer Chemistry for Accident Prevention. | | reaction suitability | reaction type: Grignard Reaction | | Synthesis | Nitrogen was replaced 3 times in a 500L reactor, 25.25kg of magnesium balls (0.8cm) were added, 100L of 2-methyltetrahydro was added and the initiator (2-bromopropane Grignard reagent) was 2kg.
furan and initiator (2-bromopropane Grignard reagent) 2kg, heated to 60-65 degrees reflux, slowly at 50-60 degrees dropwise addition of 123kg of 2- bromopropane and 120L of
2-methyltetrahydrofuran mixture, to make a clear and transparent light brown to light gray liquid, dropwise addition is completed .
reflux for 2 hours, acid-base titration concentration of 3.02 mol, reduce the temperature to about 10 degrees Celsius, stationary settlement for 24 hours, a small amount of black suspension
and precipitate deposited at the bottom of the reactor, and no other solid precipitation, the supernatant pressure into the cylinder. |
| | ISOPROPYLMAGNESIUM BROMIDE Preparation Products And Raw materials |
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