Fmoc-NH-PEG12-CH2CH2COOH manufacturers
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| | Fmoc-NH-PEG12-CH2CH2COOH Basic information | | Purity |
| Product Name: | Fmoc-NH-PEG12-CH2CH2COOH | | Synonyms: | Fmoc-nh-peg(16)-cooh;(Fmoc-amino)-PEG12-C2-Carboxylic Acid;5,8,11,14,17,20,23,26,29,32,35,38-Dodecaoxa-2-azahentetracontanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester;Fmoc-nh-peg12-C2-cooh;Carboxy-PEG12-(Fmoc-amine);Inhibitor,Fmoc-NH-PEG-12-CH2CH2COOH,inhibit,Fmoc NH PEG12 CH2CH2COOH,PROTAC Linkers,FmocNHPEG12CH2CH2COOH;FmocNH-PEG12-CH2CH2COOH/5,8,11,14,17,20,23,26,29,32,35,38-Dodecaoxa-2-azahentetracontanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester;Fmoc-N-amido-PEG12-propionic acid | | CAS: | 1952360-91-6 | | MF: | C42H65NO16 | | MW: | 839.96 | | EINECS: | | | Product Categories: | Fmoc | | Mol File: | 1952360-91-6.mol |  |
| | Fmoc-NH-PEG12-CH2CH2COOH Chemical Properties |
| Boiling point | 870.4±65.0 °C(Predicted) | | density | 1.175±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | form | clear liquid | | pka | 4.28±0.10(Predicted) | | color | Colorless to Light yellow | | InChIKey | JYNHRDJTWNEGJE-UHFFFAOYSA-N | | SMILES | C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O |
| | Fmoc-NH-PEG12-CH2CH2COOH Usage And Synthesis |
| Purity | ＞98% | | Description | Fmoc-NH-PEG12-CH2CH2COOH (CAS 1952360-91-6), also known as Fmoc-N-amido-PEG12-acid, Fmoc-NH-PEG(12)-COOH, (Fmoc-amino)-PEG12-C2-Carboxylic Acid and FmocNH-PEG12-CH2CH2COOH, is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | | Uses | Fmoc-NH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | General Description |
FmocNH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker. Fmoc-NH-PEG12-CH2CH2COOH can be used in the synthesis of PROTAC.
| | Hazard | Fmoc-NH-PEG12-CH2CH2COOH is a irritant. Contact may cause skin irritation and severe eye irritation. | | IC 50 | PEGs | | storage | Keep in dark place,Inert atmosphere,Store in freezer, under -20 ℃. | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Fmoc-NH-PEG12-CH2CH2COOH Preparation Products And Raw materials |
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