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Fmoc-n-amido-peg10-acid manufacturers
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| | Fmoc-n-amido-peg10-acid Basic information |
| Product Name: | Fmoc-n-amido-peg10-acid | | Synonyms: | Fmoc-NH-PEG10-OH;Fmoc-NH-PEG10-acid;5,8,11,14,17,20,23,26,29,32-Decaoxa-2-azapentatriacontanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester;Fmoc-NH-PEG10-propionic acid;inhibit,PROTAC Linkers,Inhibitor,FmocNHPEG10acid,Fmoc-NH-PEG-10-acid,Fmoc NH PEG10 acid;FmocNH-PEG10-CH2CH2COOH/5,8,11,14,17,20,23,26,29,32-Decaoxa-2-azapentatriacontanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester;FmocNH-PEG10-C2-COOH;Fmoc-N-amido-PEG10-acid Fmoc- | | CAS: | 2101563-45-3 | | MF: | C38H57NO14 | | MW: | 751.86 | | EINECS: | | | Product Categories: | | | Mol File: | 2101563-45-3.mol |  |
| | Fmoc-n-amido-peg10-acid Chemical Properties |
| Boiling point | 826.4±65.0 °C(Predicted) | | density | 1.181±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 4.28±0.10(Predicted) | | form | Viscous Liquid | | color | Colorless to off-white |
| | Fmoc-n-amido-peg10-acid Usage And Synthesis |
| Description | Fmoc-N-amido-PEG10-acid is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | | Uses | Fmoc-NH-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Fmoc-n-amido-peg10-acid Preparation Products And Raw materials |
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