N-Mal-N-bis(PEG4-acid) manufacturers
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| | N-Mal-N-bis(PEG4-acid) Basic information |
| Product Name: | N-Mal-N-bis(PEG4-acid) | | Synonyms: | Acid-apeg8-acid n-c3-maleimide;N-Mal-N-bis(PEG4-acid);Mal-N-bis(PEG4-C2-acid);4,7,10,13,19,22,25,28-Octaoxa-16-azahentriacontanedioic acid, 16-[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]-;16-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl)-4,7,10,13,19,22,25,28-octaoxa-16-azahentriacontanedioic acid | | CAS: | 2100306-52-1 | | MF: | C29H48N2O15 | | MW: | 664.7 | | EINECS: | | | Product Categories: | | | Mol File: | 2100306-52-1.mol |  |
| | N-Mal-N-bis(PEG4-acid) Chemical Properties |
| Boiling point | 805.1±65.0 °C(Predicted) | | density | 1.259±0.06 g/cm3(Predicted) | | solubility | Soluble in DMSO, DCM, DMF | | pka | 3.97±0.10(Predicted) | | form | Liquid | | color | Colorless to light yellow |
| | N-Mal-N-bis(PEG4-acid) Usage And Synthesis |
| Description | N-Mal-N-bis(PEG4-acid) is an Maleimide PEG reagent with two terminal carboxylic acids and a maleimide (Mal) group. Maleimide (Mal) reacts specifically with sulfhydryl groups to form a stable thioether linkage when the pH is between 6.5 and 7.5. The terminal carboxylic acids can conjugate with iamine-containing molecule in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | | Uses | Mal-N-bis(PEG4-C2-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N-Mal-N-bis(PEG4-acid) Preparation Products And Raw materials |
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