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- Mal-amido-PEG6-acid
-
-
2025-06-07
- CAS:1334177-79-5
- Min. Order: 1g
- Purity: >98.00%
- Supply Ability: 1g
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| | Mal-PEG6-COOH Basic information |
| Product Name: | Mal-PEG6-COOH | | Synonyms: | MaleiMide-NH-PEG6-CH2CH2COOH;Mal-amido-PEG6-acid;Maleimide-PEG6-propionic acid;MAL-AMIDO-PEG6-COOH;Mal-NH-PEG6-COOH;Mal-PEG6-COOH;MALEIMIDE-NH-PEG6-;4,7,10,13,16,19-Hexaoxa-22-azapentacosanoic acid, 25-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-23-oxo- | | CAS: | 1334177-79-5 | | MF: | C22H36N2O11 | | MW: | 504.53 | | EINECS: | | | Product Categories: | Heterobifunctional PEG;peg | | Mol File: | 1334177-79-5.mol |  |
| | Mal-PEG6-COOH Chemical Properties |
| Boiling point | 702.5±60.0 °C(Predicted) | | density | 1.241±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | pka | 4.28±0.10(Predicted) | | form | Solid | | color | Off-white to gray | | InChI | InChI=1S/C22H36N2O11/c25-19(3-6-24-20(26)1-2-21(24)27)23-5-8-31-10-12-33-14-16-35-18-17-34-15-13-32-11-9-30-7-4-22(28)29/h1-2H,3-18H2,(H,23,25)(H,28,29) | | InChIKey | WKTGEZMXNNBFEZ-UHFFFAOYSA-N | | SMILES | C(O)(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O |
| | Mal-PEG6-COOH Usage And Synthesis |
| Description | Mal-amido-PEG6-acid is a PEG linker containing a maleimide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. | | Uses | Mal-amido-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005 |
| | Mal-PEG6-COOH Preparation Products And Raw materials |
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