E3 ligase Ligand-Linker Conjugates 15 manufacturers
|
| | E3 ligase Ligand-Linker Conjugates 15 Basic information |
| Product Name: | E3 ligase Ligand-Linker Conjugates 15 | | Synonyms: | E3 ligase Ligand-Linker Conjugates 15;Cereblon Ligand-Linker Conjugates 7;Butanoic acid, 4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]-;4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butanoic acid;Thalidomide-O-amido-C3-carboxylic acid;4-[[2-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]oxyacetyl]amino]butanoic acid;4-(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamido)butanoic acid;4-[[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butanoic acid | | CAS: | 2308035-51-8 | | MF: | C19H19N3O8 | | MW: | 417.37 | | EINECS: | | | Product Categories: | | | Mol File: | 2308035-51-8.mol |  |
| | E3 ligase Ligand-Linker Conjugates 15 Chemical Properties |
| storage temp. | 2-8°C, stored under nitrogen | | solubility | DMSO: ≥ 55.5 mg/mL (132.98 mM) | | form | Solid | | color | White to off-white |
| | E3 ligase Ligand-Linker Conjugates 15 Usage And Synthesis |
| Uses | Thalidomide-O-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. | | IC 50 | Cereblon | | References | [1] Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.[Content Brief] DOI:10.1038/nature13527 |
| | E3 ligase Ligand-Linker Conjugates 15 Preparation Products And Raw materials |
|