| Company Name: |
Sichuan Wei Keqi Biological Technology Co., Ltd.
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| Tel: |
028-81700200 18116577057 |
| Email: |
3003855609@qq.com |
| Products Intro: |
Product Name:Thalidomide-NH-PEG2-C2-NH2TFA
CAS:2097509-36-7
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg；500mg；1g
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Thalidomide-NH-PEG2-C2-NH2 (TFA) manufacturers
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| | Thalidomide-NH-PEG2-C2-NH2 (TFA) Basic information |
| Product Name: | Thalidomide-NH-PEG2-C2-NH2 (TFA) | | Synonyms: | Thalidomide-NH-PEG2-C2-NH2 (TFA);Thalidomide-PEG2-C2-NH2 (TFA);Thalidomide-NH-PEG2-NH2 TFA;Thalidomide-4-NH-PEG2-NH2 TFA;4-[2-[2-(2-aminoethoxy)ethoxy]ethylamino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione;4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 2,2,2-trifluoroacetate;1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-(2-aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-, 2,2,2-trifluoroacetate (1:1) | | CAS: | 2097509-36-7 | | MF: | C21H25F3N4O8 | | MW: | 518.45 | | EINECS: | | | Product Categories: | | | Mol File: | 2097509-36-7.mol |  |
| | Thalidomide-NH-PEG2-C2-NH2 (TFA) Chemical Properties |
| form | Solid | | color | Light yellow to yellow |
| | Thalidomide-NH-PEG2-C2-NH2 (TFA) Usage And Synthesis |
| Uses | Thalidomide-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1]. | | IC 50 | Cereblon | | References | [1] Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163. DOI:10.1021/acs.jmedchem.9b00919 |
| | Thalidomide-NH-PEG2-C2-NH2 (TFA) Preparation Products And Raw materials |
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