Thalidomide-NH-C6-NH2 TFA

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Thalidomide-NH-C6-NH2 TFA Basic information
Product Name:Thalidomide-NH-C6-NH2 TFA
Synonyms:Thalidomide-NH-C6-NH2 TFA;Pomalidomide Related Compound 11 Triflate;4-((6-Aminohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 2,2,2-trifluoroacetate;1H-Isoindole-1,3(2H)-dione, 4-[(6-aminohexyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, 2,2,2-trifluoroacetate (1:1)
CAS:2093386-51-5
MF:C21H25F3N4O6
MW:486.45
EINECS:
Product Categories:
Mol File:2093386-51-5.mol
Thalidomide-NH-C6-NH2 TFA Structure
Thalidomide-NH-C6-NH2 TFA Chemical Properties
solubility Soluble in DMSO
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
Thalidomide-NH-C6-NH2 TFA Usage And Synthesis
UsesThalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Biological ActivityThalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
IC 50Cereblon
References[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.
Thalidomide-NH-C6-NH2 TFA Preparation Products And Raw materials
Tag:Thalidomide-NH-C6-NH2 TFA(2093386-51-5) Related Product Information
Thalidomide-NH-PEG2-C2-NH2 (TFA) Thalidomide-O-amido-C2-NH2 4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione 4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl E3 ligase Ligand-Linker Conjugates 15 Thalidomide-O-amido-C2-NH2 Thalidomide-NH-C4-NH-Boc Thalidomide-NH-C4-NH2 TFA Pomalidomide-C5-NH2 hydrochloride Thalidomide-NH-PEG2-C2-NH2 hydrochloride 5-[[2-(2-aminoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)- 2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]- 1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)- 5-[(8-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, 1H-Isoindole-1,3(2H)-dione, 4-(2-aminoethoxy)-2-(2,6-dioxo-3-piperidinyl)- β-Alanine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]- 5-[(5-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione,