- Corilagin
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- $43.00 / 5mg
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2026-04-14
- CAS:23094-69-1
- Min. Order:
- Purity: 99.99%
- Supply Ability: 10g
- Corilagin
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- $0.00 / 20mg
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2023-02-24
- CAS:23094-69-1
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
- CORILAGIN
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- $3.00 / 1KG
-
2020-01-19
- CAS:23094-69-1
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1kg,5kg,50kg
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| | CORILAGIN Basic information |
| Product Name: | CORILAGIN | | Synonyms: | 1-O-Galloyl-3-O,6-O-[2,2',3,3',4,4'-hexahydroxy[1,1'-biphenyl]-6,6'-diylbiscarbonyl]-β-D-glucopyranose;Galloyl 3-O,6-O-[(4,4',5,5',6,6'-hexahydroxy-1,1'-biphenyl-2,2'-diyl)biscarbonyl]-β-D-glucopyranoside;CORILAGIN(SH);CORILAGIN;B-D-GLUCOPYRANOSE, CYCLIC 3,6-(4,4',5,5',6,6'-HEXAHYDROXY[1,1'-BIPHENYL]-2,2'-DICARBOXYLATE)1-(3,4,5-TRIHYDROXYBENZOATE), (R)-;1-O-GALLOYL-3,6-HEXAHYDROXYDIPHENOYL-BETA-D-GLUCOPYRANOSE;CORILAGIN: B-D-GLUCOPYRANOSE, CYCLIC3,6-(4,4',5,5',6,6'-HEXAHYDROXY[1,1'-BIPHENYL]-2,2'-DICARBOXYLATE)1-(3,4,5-TRIHYDROXYBENZOATE), (R)-,;1-O-Galloyl-3,6-hexahydroxydiphenol-b-D-Glucopyranose | | CAS: | 23094-69-1 | | MF: | C27H22O18 | | MW: | 634.46 | | EINECS: | | | Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Carbohydrates & Derivatives;Miscellaneous Natural Products | | Mol File: | 23094-69-1.mol |  |
| | CORILAGIN Chemical Properties |
| Melting point | >200°C dec | | Boiling point | 1280.8±65.0 °C(Predicted) | | density | 2.11±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,2-8°C | | solubility | H2O: soluble1mg/mL, clear, colorless | | pka | 7.53±0.70(Predicted) | | form | Solid | | color | Off-White | | Water Solubility | H2O: 1mg/mL, clear, colorless | | Stability: | Hygroscopic | | Major Application | food and beverages | | InChIKey | TUSDEZXZIZRFGC-XIGLUPEJSA-N | | SMILES | OC1C(=C(O)C=C2C(OC3C(O)C(OC(OC(C4C=C(O)C(O)=C(O)C=4)=O)C3O)COC(=O)C3=CC(O)=C(O)C(O)=C3C=12)=O)O |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | CORILAGIN Usage And Synthesis |
| Description | Corilagin is a polyphenol and hydrolyzable tannin that can be isolated from a variety of plants. It inhibits squalene epoxidase (IC50 = 4.0 μM), a key enzyme in cholesterol synthesis. Corilagin also has various anti-inflammatory and anti-cancer effects. | | Chemical Properties | Off-White Solid | | Uses | Thrombolytic. | | Definition | ChEBI: An ellagitannin with a hexahydroxydiphenoyl group bridging over the 3-O and 6-O of the glucose core. | | in vivo | Corilagin (15 mg/kg, i.p., for 7 days) shows anti-tumor activity in Hep3B hepatocellular carcinoma[4].
Corilagin (0-20 mg/kg, i.p.) prevents APAP-induced hepatotoxicity in mice[5].
Corilagin (10 and 100 mg/kg, i.p.) ameliorates Bleomycin-induced pulmonary fibrosis in mice[6].
| Animal Model: | Hep3B hepatocellular carcinoma mouse model[4]. | | Dosage: | 15 mg/kg | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Inhibited tumor growth without toxic effects. |
| Animal Model: | APAP-induced hepatotoxicity in mice[5] | | Dosage: | 0, 1, 5, 10, 20 mg/kg | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Decreased APAP-induced serum ALT level, hepatic myeloperoxidase (MPO) activity, cytokines (TNF-α, IL-1β, and IL-6) production, malondialdehyde (MDA) activity, and ERK/JNK MAPK and NF-κB protein expressions. |
| | References | [1] IKURO ABE. Ellagitannins and Hexahydroxydiphenoyl Esters as Inhibitors of Vertebrate Squalene Epoxidase[J]. Journal of Natural Products , 2001, 64 8: 1010-1014. DOI: 10.1021/np010100y
[2] ROBERTO GAMBARI . Corilagin is a potent inhibitor of NF-kappaB activity and downregulates TNF-alpha induced expression of IL-8 gene in cystic fibrosis IB3-1 cells[J]. International immunopharmacology, 2012, 13 3: Pages 308-315. DOI: 10.1016/j.intimp.2012.04.010
[3] HAI-TAO XIAO. Inhibitory Effect of the Gallotannin Corilagin on Dextran Sulfate Sodium-Induced Murine Ulcerative Colitis[J]. Journal of Natural Products , 2013, 76 11: 2120-2125. DOI: 10.1021/np4006772
[4] LUOQI JIA. A potential anti-tumor herbal medicine, Corilagin, inhibits ovarian cancer cell growth through blocking the TGF-β signaling pathways.[J]. BMC Complementary and Alternative Medicine, 2013: 33. DOI: 10.1186/1472-6882-13-33
[5] ROBERTO GAMBARI. Sensitization of Hep3B hepatoma cells to cisplatin and doxorubicin by corilagin.[J]. Phytotherapy Research, 2014, 28 5: 781-783. DOI: 10.1002/ptr.5049 |
| | CORILAGIN Preparation Products And Raw materials |
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