Cyclic-di-GMP disodium NEW
| Price | $139 | $372 | $513 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-06-05 |
Product Details
| Product Name: Cyclic-di-GMP disodium | CAS No.: 2222132-40-1 |
| Purity: 99.93% | Supply Ability: 10g |
| Release date: 2025/06/05 |
Product Introduction
Bioactivity
| Name | Cyclic-di-GMP disodium |
| Description | Cyclic-di-GMP disodium (5GP-5GP disodium) is a STING agonist and a second messenger in bacteria. It is involved in a variety of processes in prokaryotes, including biofilm formation, motility, and cell cycle progression. Cyclic-di-GMP disodium (5GP-5GP disodium) exhibits antiproliferative activity against cancer cells, inducing increased CD4 receptor expression and cell cycle arrest, and is a novel therapeutic agent that can be developed to prevent or treat cancer. |
| In vitro | METHODS: H508 cells were treated with cyclized-di-GMP disodium (5GP-5GP disodium) (0.5-50 μM, 5 days) and cell proliferation was measured using a validated sulforhodamine B (SRB) colorimetric assay. RESULTS The highest concentration (50 μM) of c-di-GMP reduced H508 cell proliferation by approximately 15%. [1] METHODS: Cyclic-di-GMP disodium (5GP-5GP disodium) (50, 100μM) was used to treat Jur kat cells, and the CD4 level in the cells was observed. RESULTS Cyclic-di-GMP disodium (5GP-5GP disodium) at a concentration of 50μM can induce a 6.3-fold increase in CD4 levels in Jur kat cells, and this was dose-dependent. Cyclic-di-GMP disodium (5GP-5GP disodium) at a concentration of 100μM treated Jur kat cells, resulting in a 9.1-fold increase in CD4 compared to the control group. [2] |
| In vivo | METHODS: Cyclic-di-GMP disodium (5GP-5GP disodium) (100 μg, intravenous injection) was used in mice in the primary and booster phases to verify whether it would further enhance the immune response to TriVax. RESULTS Cyclic-di-GMP disodium (5GP-5GP disodium) can effectively enhance the magnitude of the immune response produced by TriVax. [3] |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 144.0 mg/mL (196.1 mM), Sonication is recommended. |
| Keywords | STING | EndogenousMetabolite | Endogenous Metabolite | Cyclic-di-GMP disodium | Cyclic di-GMP | CD4 |
| Inhibitors Related | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | L-Methionine | Oleamide | Glycerol | Thymidine | Naringin | L-Ascorbic acid sodium salt | 3-Indoleacetic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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