tyclopyrazoflor manufacturers
- Tyclopyrazoflor
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- $524.00
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2026-04-21
- CAS:1477919-27-9
- Purity:
- Supply Ability: 10g
- Tyclopyrazoflor
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- $1520.00
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2025-08-22
- CAS:1477919-27-9
- Purity:
- Supply Ability: 10g
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| | tyclopyrazoflor Basic information |
| Product Name: | tyclopyrazoflor | | Synonyms: | tyclopyrazoflor;Propanamide, N-[3-chloro-1-(3-pyridinyl)-1H-pyrazol-4-yl]-N-ethyl-3-[(3,3,3-trifluoropropyl)thio]- | | CAS: | 1477919-27-9 | | MF: | C16H18ClF3N4OS | | MW: | 406.85 | | EINECS: | | | Product Categories: | | | Mol File: | 1477919-27-9.mol |  |
| | tyclopyrazoflor Chemical Properties |
| | tyclopyrazoflor Usage And Synthesis |
| Uses | Tyclopyrazoflor is an anthranilamide compound with pesticidal activity. | | Definition | ChEBI: Tyclopyrazoflor is a member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 4 by a pyridin-3-yl group, chloro group and an ethyl{3-[(3,3,3-trifluoropropyl)sulfanyl]propanoyl}nitrilo group, respectively. It is an insecticide from Dow AgroSciences LLC. It has a role as an insecticide. It is an organofluorine compound, a member of pyrazoles, a member of pyridines, a tertiary carboxamide, an organic sulfide and an organochlorine compound. | | Production Methods | Tyclopyrazoflor is produced commercially through a process that begins with a [3+2] cyclization of 3-hydrazinopyridine hydrochloride and methyl acrylate to form a pyrazolidinone, followed by chlorination and oxidation to a disubstituted pyrazole. Regioselective nitration, reduction to the aminopyrazole, and acylation with 3-((3,3,3-trifluoropropyl)thio)propanoyl chloride yield a secondary amide intermediate, which is then alkylated to the final product. Key innovations include a thiol-ene reaction for the trifluoropropyl thioester precursor, achieving high regioselectivity using a benzoyl peroxide/N,N-dimethylaniline initiator system at low temperatures in semibatch mode, and an Ullmann coupling of N-(3-chloro-1H-pyrazol-4-yl)acetamide with 3-bromopyridine, catalysed by copper(I) chloride and 1,2-dimethylethylenediamine. | | Mechanism of action | Unclear but thought to interfer with an insect's nervous system, specifically its neurotransmission, interacting with the chordotonal TRPV channels | | References | [1] WO 2017140563 A1. | | Pesticide Type | Insecticide |
| | tyclopyrazoflor Preparation Products And Raw materials |
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