APN-C3-PEG4-alkyne manufacturers
- APN-C3-PEG4-alkyne
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2025-06-07
- CAS:2183440-36-8
- Min. Order: 25mg
- Purity: >98.00%
- Supply Ability: 25mg
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| | APN-C3-PEG4-alkyne Basic information |
| | APN-C3-PEG4-alkyne Chemical Properties |
| | APN-C3-PEG4-alkyne Usage And Synthesis |
| Description | APN-C3-PEG4-alkyne is a heterobifunctional linker containing an APN moiety with exquisite chemoselectivity for cysteine and an alkyne group. The superior stability of APN-cysteine conjugates in aqueous media, human plasma, and living cells makes this new thiol-click reaction a promising methodology for applications in bioconjugation. | | Uses | APN-C3-PEG4-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. APN-C3-PEG4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | APN-C3-PEG4-alkyne Preparation Products And Raw materials |
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