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| | Nicotinic acid hydrazide Basic information |
| | Nicotinic acid hydrazide Chemical Properties |
| Melting point | 159-161 °C(lit.) | | Boiling point | 251.97°C (rough estimate) | | density | 1.2620 (rough estimate) | | refractive index | 1.6910 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | H2O: soluble50mg/mL | | form | Fine Needle-Like Crystalline Powder | | pka | 11.43±0.10(Predicted) | | color | White to off-white | | Water Solubility | Soluble in alcohol, water. | | BRN | 119299 | | InChI | InChI=1S/C6H7N3O/c7-9-6(10)5-2-1-3-8-4-5/h1-4H,7H2,(H,9,10) | | InChIKey | KFUSANSHCADHNJ-UHFFFAOYSA-N | | SMILES | C1=NC=CC=C1C(NN)=O | | CAS DataBase Reference | 553-53-7(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 22-26-36/37/39 | | RIDADR | UN2811 | | WGK Germany | 3 | | RTECS | QT1750000 | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29280000 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2 | | Toxicity | LD50 intravenous in mouse: 180mg/kg |
| | Nicotinic acid hydrazide Usage And Synthesis |
| Chemical Properties | WHITE TO OFF-WHITE FINE NEEDLE-LIKE CRYST. POWDER | | Uses | An Impurity of Isoniazid (I821450), potent antitubercular agent against M. tuberculosis. | | Uses | Nicotinic hydrazide was used in hydrazone library formation. It was used to study the oxidation of isonicotinic acid hydrazide (isoniazid) by horseradish peroxidase. | | Biochem/physiol Actions | Nicotinic hydrazide is an inhibitor of peroxidase enzyme. It forms solid metal complexes having strong biological activity. | | Synthesis | The general procedure for the synthesis of 3-pyridinecarbohydrazide from methyl nicotinate was as follows: accurately weigh methyl 3-pyridinecarboxylate (2.74 g, 20 mmol) in a 50 mL round-bottomed flask, add anhydrous ethanol (15 mL), and stir at room temperature until the solid was completely dissolved. Subsequently, 80% hydrazine hydrate (30 mmol) was slowly added dropwise and immediately a large amount of needle-like white solid was observed to precipitate. The reaction mixture was continued to be stirred at room temperature for 3 h. Upon completion of the reaction, diafiltration was carried out and the solid was washed with a small amount of ethanol, resulting in 2.56 g of white needle-like crystals in 93.2% yield. | | Purification Methods | Crystallise it from aqueous EtOH or *benzene. [Beilstein 22 III/IV 439, 22/2 V 121.] | | References | [1] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 7, p. 1381 - 1387
[2] Patent: CN104592217, 2018, B. Location in patent: Paragraph 0032; 0033; 0034
[3] Patent: WO2017/11466, 2017, A1. Location in patent: Paragraph 00473
[4] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 6, p. 2158 - 2171
[5] Patent: CN108484582, 2018, A. Location in patent: Paragraph 0031; 0036; 0037; 0038; 0039 |
| | Nicotinic acid hydrazide Preparation Products And Raw materials |
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