NICOTINIC ACID MONONUCLEOTIDE manufacturers
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| | NICOTINIC ACID MONONUCLEOTIDE Basic information |
| | NICOTINIC ACID MONONUCLEOTIDE Chemical Properties |
| Melting point | >115°C (dec.) | | storage temp. | −20°C | | solubility | Methanol (Slightly, Heated), Water(Slightly) | | pka | 1.856±0.10(predicted) | | form | Solid | | color | White to Off-White | | biological source | animal | | Stability: | Hygroscopic | | InChI | InChI=1/C11H14NO9P/c13-8-7(5-20-22(17,18)19)21-10(9(8)14)12-3-1-2-6(4-12)11(15)16/h1-4,7-10,13-14H,5H2,(H2-,15,16,17,18,19)/t7-,8-,9-,10-/s3 | | InChIKey | JOUIQRNQJGXQDC-NLNRFTKUNA-N | | SMILES | [C@@H]1([C@H](O)[C@H](O)[C@@H](COP([O-])(=O)O)O1)[N+]1C=CC=C(C(=O)O)C=1 |&1:0,1,3,5,r| |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | NICOTINIC ACID MONONUCLEOTIDE Usage And Synthesis |
| Uses | A nucleotide of nicotinic acid which is produced from quinolinic acid by quinolinate phosphoribosyltransferase via transfer of a phosphoribose group. It is an intermediate of nicotinic acid adenine dinucleotide (NaAD) which is then converted to NAD via amidation and in turn converted to NADPH. | | Biological Activity | Nicotinic acid mononucleotide (NaMN) may be used to study the relationship between the phosphate-responsive signaling (PHO) pathway and nicotine adenine dinucleotide (NAD(+)) metabolism in yeast. Nicotinate mononucleotide is a substrate for NMN/NaMN adenylyltransferase (NMNAT) and nicotinate mononucleotide adenylyltransferase. NaMN amidation results in the synthesis of nicotinamide mononucleotide(NMN), which is further converted to NAD cofactor. | | Synthesis | Nicotinic acid mononucleotide is prepared by the reaction of 2,3-dicarboxypyridine and 5-phosphoribosyl-1-pyrophosphate. The steps are as follows:
With phosphoribosyl pyrophosphate-quinolinate phosphoribosyltransferase; magnesium chloride In aq. phosphate buffer at 37℃; for 6h; pH=7.0; Enzymatic reaction.
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| | NICOTINIC ACID MONONUCLEOTIDE Preparation Products And Raw materials |
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