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Schisandrin A

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Products Intro: Product Name:Schisandrin A
CAS:61281-38-7
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CAS:61281-38-7
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CAS:61281-38-7
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CAS:61281-38-7
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Products Intro: Product Name:Schisandrin a
CAS:61281-38-7
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  • Schisandrin A
  • Schisandrin A pictures
  • $0.10 / 1KG
  • 2026-02-02
  • CAS:61281-38-7
  • Min. Order: 0.10000000149011612KG
  • Purity: 98%
  • Supply Ability: 200TONS
Schisandrin A Basic information
Product Name:Schisandrin A
Synonyms:SCHISANDRIN A (DEOXYSCHISANDRIN);SCHISANDRA CHINENSIS PLANT EXTRACT 9+% SCHISANDRINS;SCHISANDRA CHINENSIS PLANT EXTRACT 5+% SCHISANDRINS;SCHISANDRA PLANT EXTRACT;SCHISANDRA BERRY POWDER;SCHISANDRIN A, (DEOXYSCHISANDRIN) 98% BY HPLC;SCHISANDRA CHINENSIS PLANT EXTRACT 2+% SCHISANDRINS;DEOXYSCHIZANDRIN90%,99%
CAS:61281-38-7
MF:C24H32O6
MW:416.51
EINECS:
Product Categories:Miscellaneous Natural Products;Inhibitors;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol File:61281-38-7.mol
Schisandrin A Structure
Schisandrin A Chemical Properties
Melting point 116-117 °C
Boiling point 544.2±50.0 °C(Predicted)
density 1.080±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
form powder
color White to Off-White
Major Applicationmetabolomics
vitamins, nutraceuticals, and natural products
InChI1S/C24H32O6/c1-13-9-15-11-17(25-3)21(27-5)23(29-7)19(15)20-16(10-14(13)2)12-18(26-4)22(28-6)24(20)30-8/h11-14H,9-10H2,1-8H3/t13-,14+
InChIKeyJEJFTTRHGBKKEI-OKILXGFUSA-N
SMILESC[C@@H](C1)[C@H](C)CC2=C(C3=C1C=C(OC)C(OC)=C3OC)C(OC)=C(OC)C(OC)=C2
LogP5.870 (est)
Safety Information
Safety Statements 24/25
WGK Germany 3
RTECS HP1595000
HS Code 29093090
Storage Class11 - Combustible Solids
MSDS Information
Schisandrin A Usage And Synthesis
DescriptionSchisandrin A is a lignan that has been found in Schisandra and has diverse biological activities. It binds to adiponectin receptor 2 (IC50 = 3.2 μM). Schisandrin A (10, 20, and 50 μM) reduces LPS-induced production of nitric oxide (NO), IL-6, and TNF-α and apoptosis in primary mouse microglial cells. It reverses P-glycoprotein-mediated doxorubicin resistance in MCF-7/dox cells when used at a concentration of 20 μM. Schisandrin A (4, 12, and 36 mg/kg) reverses short-term and spatial memory deficits, as well as decreases in cerebral superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities induced by amyloid β (1-42) (Aβ42; ) in a mouse model of Alzheimer’s disease.
Chemical PropertiesWhite powder
UsesSchizandrin A is an extract from Schisandra chinesis. a dibenzocyclooctadiene lignan with antiinflammatory activity.
in vivo

Schisandrin A (SchA) significantly inhibits CYP3A activity in rat hepatic microsomes and Vmax value of each group in a concentration-dependent manner. The double-reciprocal plots and the secondary plot show that Schisandrin A inhibits CYP3A activity, with an apparent Ki value of 30.67 mg/kg. In each Schisandrin A-treated group, Schisandrin A also significantly decreases 1-hydroxymidazolam plasma concentrations compared with the negative group (to levels similar to the positive group)[2].

IC 50CYP3A: 6.6 μM (IC50); Autophagy
References[1] YIYI SUN. Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay.[J]. PLoS ONE, 2013: e63354. DOI: 10.1371/journal.pone.0063354
[2] FANG-JIAO SONG. Schizandrin A Inhibits Microglia-Mediated Neuroninflammation through Inhibiting TRAF6-NF-κB and Jak2-Stat3 Signaling Pathways[J]. PLoS ONE, 2016, 11 1. DOI: 10.1371/journal.pone.0149991
[3] ZONG-LIN ZHANG  Su R W  Qing Cheng Jiang. Schisandrin A reverses doxorubicin-resistant human breast cancer cell line by the inhibition of P65 and Stat3 phosphorylation.[J]. Breast Cancer, 2018, 25 2: 233-242. DOI: 10.1007/s12282-017-0821-9
[4] DI HU. Deoxyschizandrin isolated from the fruits of Schisandra chinensis ameliorates Aβ-induced memory impairment in mice.[J]. Planta medica, 2012, 78 12: 1332-1336. DOI: 10.1055/s-0032-1315019
Schisandrin A Preparation Products And Raw materials
Tag:Schisandrin A(61281-38-7) Related Product Information
SCHISANDRIN (SCHISANDROL A),SCHISANDRIN,Schisandrin（Schizandrol A） SCHISANDRIN(SCHISANDROL A)(P),SCHISANDRIN, GAMMA-,S(-)-SCHISANDRIN,S(-) SCHISANDRIN B,GAMMA-SCHISANDRIN,SCHISANDRIN B schisanhenol Baicalin Asiaticoside Silybin Podophyllotoxin 2-BUTENOIC ACID, 2-METHYL-, (5S,6S,7S,13AS)-5,6,7,13A-TETRAHYDRO-6-HYDROXY-1,2,3,13-TETRAMETHOXY-6,7-DIMETHYLBENZO[3,4]CYCLOOCTA[1,2-F][1,3]BENZODIOXOL-5-YL ESTER, (2Z)- WUWEIZISU C Schisantherin A Gomisin A SCHISANTHERIN C 98+% HPLC Schisandrin C γ-Schisandrin Schisandrin A SCHISANDRIN SNAP-N-SHOOT 0.1mg/mL(P) Schizandra Chinesis (9% Schisandrin) SCHISANDRIN, gamma- SNAP-N-SHOOT 0.1mg/mL(P),SCHISANDRIN, gamma-(AHP)