- Catalpol
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- $34.00 / 1mL
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2026-01-26
- CAS:2415-24-9
- Min. Order:
- Purity: 99.89%
- Supply Ability: 10g
- Catalpol
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- $0.00 / 25kg
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2025-12-01
- CAS:2415-24-9
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 10000kgs
- Catalpol
-
- $0.00 / 25kg
-
2025-12-01
- CAS:2415-24-9
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10000KGS
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| | Catalpol Basic information |
| Product Name: | Catalpol | | Synonyms: | CATALPOL;CATAPOL;,6-beta,6a-alpha))-;beta-d-glucopyranoside,1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl);catalpinoside;de(p-hydroxybenzoyl)catalposide;des-p-hydroxybenzoyl-catalposid;oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl,(1as-(1a-alpha,1b-beta,2-beta,5a-beta | | CAS: | 2415-24-9 | | MF: | C15H22O10 | | MW: | 362.33 | | EINECS: | 219-324-0 | | Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;Iridoids | | Mol File: | 2415-24-9.mol |  |
| | Catalpol Chemical Properties |
| Melting point | 203-205°C | | Boiling point | 675.6±55.0 °C(Predicted) | | density | 1.72±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly) | | form | Solid | | pka | 12.79±0.70(Predicted) | | color | White to Off-White | | InChI | InChI=1/C15H22O10/c16-3-6-9(19)10(20)11(21)14(23-6)24-13-7-5(1-2-22-13)8(18)12-15(7,4-17)25-12/h1-2,5-14,16-21H,3-4H2/t5-,6-,7-,8+,9-,10+,11-,12+,13+,14+,15-/s3 | | InChIKey | LHDWRKICQLTVDL-CLLMHHLUSA-N | | SMILES | C([C@]12O[C@H]1[C@@H](O)[C@]1([H])C=CO[C@@H](O[C@@]3([H])[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)[C@]21[H])O |&1:1,3,4,6,11,13,15,16,18,20,25,r| | | LogP | -4.609 (est) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | LZ5776816 | | HS Code | 29389090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 | | Toxicity | mouse,LD,intravenous,> 2500mg/kg (2500mg/kg),Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64, Pg. 93, 1968. |
| | Catalpol Usage And Synthesis |
| Description | Catalpol is an iridoid glycoside that has been isolated from R. glutinosa and has diverse biological activities, including anti-apoptotic, pro-angiogenic, and radioprotective properties. It protects against mitochondrial pathway-dependent apoptosis in PC12 rat adrenal pheochromocytoma cells and H9c2 rat embryonic ventricular myocardial cells when used at a concentration of 10 μM. Catalpol pretreatment reduces apoptosis and improves viability in AHH-1 human lymphocyte cells exposed to ionizing radiation and reduces intestinal damage induced by radiation in mice when used at concentrations and doses ranging from of 25 to 100 μg/ml and 25 to 100 mg/kg, respectively. In a rat model of stroke, catalpol (5 mg/kg, i.p.) increases the expression of erythropoietin and VEGF and improves angiogenesis in the brain. | | Chemical Properties | Light brown powder | | Uses | Catapol is an iridoid glucoside that has been shown to alleviate neuropathic pain. | | Definition | ChEBI: Catalpol is an organic molecular entity. It has a role as a metabolite. | | in vivo | Catalpol (25-100?mg/kg; intraperitoneal injection; once) treatment clearly reduces blood urea nitrogen, serum creatinine levels and the expression of KIM-1 in renal ischemia/reperfusion-injury (IRI) mice. Catalpol markedly reduces the expression of PI3K, Akt and eNOS levels, and suppresses the TNF-α, IL-1β, IL-6 and IL-10 activities[1]. | Animal Model: | C57BL/6 mice treated with renal ischemia/reperfusion surgery[1] | | Dosage: | 25 mg/kg, 50 mg/kg and 100?mg/kg | | Administration: | Intraperitoneal injection; once | | Result: | Clearly reduced blood urea nitrogen, serum creatinine levels and the expression of KIM-1 in renal IRI mice.
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| | References | [1] YANJIE WANG. Simultaneous Determination of Catalpol, Aucubin, and Geniposidic Acid in Different Developmental Stages of Rehmannia glutinosa Leaves by High Performance Liquid Chromatography.[J]. Journal of Analytical Methods in Chemistry, 2016, 2016: 4956589. DOI: 10.1155/2016/4956589
[2] WENNA CHEN. Neuroprotective activities of catalpol against CaMKII-dependent apoptosis induced by LPS in PC12 cells[J]. British Journal of Pharmacology, 2013, 169 5: 1140-1152. DOI: 10.1111/bph.12200
[3] LING-AI HU. Catalpol inhibits apoptosis in hydrogen peroxide-induced cardiac myocytes through a mitochondrial-dependent caspase pathway.[J]. Bioscience Reports, 2016, 36 3. DOI: 10.1042/bsr20160132
[4] CHENGJIE CHEN. Radio-protective effect of catalpol in cultured cells and mice.[J]. Journal of Radiation Research, 2013, 54 1: 76-82. DOI: 10.1093/jrr/rrs080
[5] HUI-FENG ZHU. Catalpol increases brain angiogenesis and up-regulates VEGF and EPO in the rat after permanent middle cerebral artery occlusion.[J]. International Journal of Biological Sciences, 2010, 6 5: 443-453. DOI: 10.7150/ijbs.6.443 |
| | Catalpol Preparation Products And Raw materials |
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