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| | 4-Amino-6-chloropyrimidine-5-carbaldehyde Basic information |
| Product Name: | 4-Amino-6-chloropyrimidine-5-carbaldehyde | | Synonyms: | RARECHEM AK ML 0569;4-AMINO-6-CHLORO-PYRIMIDINE-5-CARBALDEHYDE;4-AMINO-6-CHLORO-5-PYRIMIDINECARBALDEHYDE;4-AMINO-6-CHLORO-5-PYRIMIDINECARBOXALDEHYDE;4-Amino-6-chloropyrimidine-5-carboxaldehyde;4-Amino-6-chloro-5-pyrimidinecarboxaldehyde ,96%;4-aMino-6-chloropyriMidin-5-carbaldehyde;5-PyriMidinecarbaldehyde, 4-aMino-6-chloro | | CAS: | 14160-93-1 | | MF: | C5H4ClN3O | | MW: | 157.56 | | EINECS: | 238-005-7 | | Product Categories: | Heterocycle-Pyrimidine series;pyrimidine | | Mol File: | 14160-93-1.mol |  |
| | 4-Amino-6-chloropyrimidine-5-carbaldehyde Chemical Properties |
| Melting point | >300°C | | Boiling point | 355.9±42.0 °C(Predicted) | | density | 1.548±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | Solid | | pka | 0.72±0.10(Predicted) | | Appearance | Off-white to light yellow Solid | | Sensitive | Air Sensitive | | InChI | InChI=1S/C5H4ClN3O/c6-4-3(1-10)5(7)9-2-8-4/h1-2H,(H2,7,8,9) | | InChIKey | GOJNFUXEBVBARW-UHFFFAOYSA-N | | SMILES | C1=NC(Cl)=C(C=O)C(N)=N1 | | EPA Substance Registry System | 5-Pyrimidinecarboxaldehyde, 4-amino-6-chloro- (14160-93-1) |
| | 4-Amino-6-chloropyrimidine-5-carbaldehyde Usage And Synthesis |
| Chemical Properties | Yellow solid | | Uses | 4-Amino-6-chloropyrimidine-5-carbaldehyde is an important pharmaceutical intermediate compound that can be used in the preparation of ENPP1 inhibitors [1]. Furthermore, it serves as a key starting material for the synthesis of novel 4-amino-pyrimidine-5-formyl oxime VEGFR-2 inhibitors [2]. | | References |
[1] Sun, Y., Chen, M., Han, Y. (2024). Discovery of Pyrido[2,3-d]pyrimidin-7-one Derivatives as Highly Potent and Efficacious Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) Inhibitors for Cancer Treatment. Journal of Medicinal Chemistry, 67 5, 3986–4006. https://doi.org/10.1021/acs.jmedchem.3c02288
[2] Huang, S., Li, R., LaMontagne, K. R., Greenberger, L. M., & Connolly, P. J. (2011). 4-Aminopyrimidine-5-carbaldehyde oximes as potent VEGFR-2 inhibitors. Part II. Bioorganic & Medicinal Chemistry Letters, 21 6, Pages 1815-1818. https://doi.org/10.1016/j.bmcl.2011.01.053
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| | 4-Amino-6-chloropyrimidine-5-carbaldehyde Preparation Products And Raw materials |
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