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| Product Name: | FX12 | | Synonyms: | Benzo[b]thiophene-2-carboxylic acid, methyl ester, 1,1-dioxide;RNF5-IN-1 | | CAS: | 1807639-36-6 | | MF: | C10H8O4S | | MW: | 224.23 | | EINECS: | | | Product Categories: | | | Mol File: | 1807639-36-6.mol |  |
| Boiling point | 436.264±45.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.456±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | solubility | Acetonitrile: Slightly soluble: 0.1-1 mg/ml
DMSO: Sparingly soluble: 1-10 mg/ml |
| Uses | RNF5-IN-1 (FX12) is a selective RNF5 degrader. RNF5-IN-1 binds to RNF5 and inhibits its E3 activity, and promotes proteasomal degradation of RNF5 in an endoplasmic reticulum (ER)-associated degradation (ERAD) way in cells. RNF5-IN-1 inhibits α-1-antitrypsin (NHK) dislocation with an IC50 value of 2.7 μM. RNF5-IN-1 can be used for research of cystic fibrosis, acute myeloid leukemia, and certain viral infections[1]. | | References | [1] Ruan J, et al. A small-molecule inhibitor and degrader of the RNF5 ubiquitin ligase. Mol Biol Cell. 2022 Nov 1;33(13):ar120. DOI:10.1091/mbc.E22-06-0233 |
| | FX12 Preparation Products And Raw materials |
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