1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]-

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1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]- Suppliers list
Company Name: Anqing YanZhi Pharma Discovery Co.,Ltd.  Gold
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Company Name: Chengdu DingDang Pharmaceutical Co., Ltd.  Gold
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Company Name: WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.  
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Company Name: Nanjing Chemlin Chemical Co., Ltd  
Tel: 025-83697070 13770331960
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1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]- manufacturers

  • KSQ-4279
  • KSQ-4279 pictures
  • $158.00
  • 2026-07-27
  • CAS:2446480-97-1
  • Purity: 99.98%
  • Supply Ability: 10g
  • KSQ-4279
  • KSQ-4279 pictures
  • 2026-07-24
  • CAS:2446480-97-1
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 1000kg
1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]- Basic information
Product Name:1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]-
Synonyms:1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]-;USP1-IN-1;6-(4-cyclopropyl-6-methoxy-pyrimidin-5-yl)-1-[[4-[1-isopropyl-4-(trifluoromethyl)imidazol-2-yl]phenyl]methyl]pyrazolo[3,4-d]pyrimidine;6-(4-Cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[4-[1-isopropyl-4-(trifluoromethyl)-2-imidazolyl]benzyl]-1H-pyrazolo[3,4-d]pyrimidine; 6-(4-Cyclopropyl-6-methoxypyrimidin-5-yl)-1-(4-(1-isopropyl-4-(trifluoromethyl)-1H-imidazol-2-yl)benzyl)-1H-pyrazolo[3,4-d]pyrimidine;KSQ-4279?(Synonyms: USP1-IN-1);1H-Pyrazolo[3,4-d]pyrimidine,?6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]-KSQ-4279;RO7623066
CAS:2446480-97-1
MF:C27H25F3N8O
MW:534.54
EINECS:
Product Categories:
Mol File:2446480-97-1.mol
1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]- Structure
1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]- Chemical Properties
density 1.47±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 80 mg/mL (149.66 mM; Need ultrasonic)
pka2.85±0.60(Predicted)
form Solid
color White to light yellow
InChIKeyKCBWAFJCKVKYHO-UHFFFAOYSA-N
SMILESC1(C2=C(OC)N=CN=C2C2CC2)=NC=C2C=NN(CC3=CC=C(C4N(C(C)C)C=C(C(F)(F)F)N=4)C=C3)C2=N1
Safety Information
MSDS Information
1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]- Usage And Synthesis
UsesKSQ-4279 (USP1-IN-1) is a potent USP1 inhibitor and a selective PARP1 inhibitor. KSQ-4279 is promising for research of cancers[1].
in vivo

KSQ-4279 shows dose-dependent, robust and durable anti-tumor regression in multiple TNBC and ovarian cancer Patient-derived xenografts (PDXs) with varied genomic status including BRCA1-mutated and -wildtype models[1].

IC 50USP1; PARP1
References[1] Natalie Y L Ngoi, et al. Targeting the DNA damage response beyond poly(ADP-ribose) polymerase inhibitors: novel agents and rational combinations. Curr Opin Oncol. 2022 Sep 1;34(5):559-569. DOI:10.1097/CCO.0000000000000867
1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]- Preparation Products And Raw materials
Tag:1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]-(2446480-97-1) Related Product Information
USP1-IN-5 USP1-IN-6 1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]- RA-9 Tos-Arg-OMe HCl 9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-[(phenylmethoxy)imino]-