2-Morpholinopyrimidin-4-ol manufacturers
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| | 2-Morpholinopyrimidin-4-ol Basic information |
| Product Name: | 2-Morpholinopyrimidin-4-ol | | Synonyms: | 2-Morpholin-4-yl-pyrimidin-4-ol;2-MorpholinopyriMidin-4(3H)-one;2-Morpholino-4(3H)-pyrimidinone;2-Morpholinopyrimidin-4-ol;4(3H)-Pyrimidinone, 2-(4-morpholinyl)-;2-(4-Morpholinyl)-4(3h)-pyrimidinone;2-morpholin-4-yl-1H-pyrimidin-6-one;2-Morpholinopyrimidin-4-ol ISO 9001：2015 REACH | | CAS: | 19810-79-8 | | MF: | C8H11N3O2 | | MW: | 181.19 | | EINECS: | | | Product Categories: | | | Mol File: | 19810-79-8.mol |  |
| | 2-Morpholinopyrimidin-4-ol Chemical Properties |
| density | 1.41 | | storage temp. | Sealed in dry,Room Temperature | | Appearance | White to off-white Solid |
| | 2-Morpholinopyrimidin-4-ol Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 2-morpholino-4-hydroxypyrimidine from 2-methylthio-4-pyrimidinone (4.0 g, 0.0281 mol) and morpholine (3.05 g, 0.035 mol): 2-methylthio-4-pyrimidinone was mixed with morpholine, heated to 145°C and maintained for 2 hours. After completion of the reaction, it was cooled to room temperature. White needle-like crystals (2.0 g) were obtained by ethanol crystallization. Subsequently, a second batch of crystals of about 0.50 g was formed in a total yield of 49%. The product was detected by mass spectrometry showing M + H = 181.1. 1H NMR (CDCl3) data were as follows: δ 12.1 (broad peak, 1H), 7.85 (double peak, 1H), 5.79 (double peak, 1H), and 3.75 (multiple peaks, 8H). | | References | [1] Patent: WO2005/28444, 2005, A1. Location in patent: Page/Page column 49 |
| | 2-Morpholinopyrimidin-4-ol Preparation Products And Raw materials |
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