ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyrimidines >Thio pyrimidine >2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester

2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester

Request For Quotation
2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester Suppliers list
Company Name: J & K SCIENTIFIC LTD.  
Tel: 18210857532 18210857532
Email: jkinfo@jkchemical.com
Company Name: BeiJing Hwrk Chemicals Limted  
Tel: 0757-86329057 18934348241
Email: sales4.gd@hwrkchemical.com
Company Name: Capot Chemical Co., Ltd  
Tel: +86 (0) 571 85 58 67 18
Email:
Company Name: Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.  
Tel: 21-57721279 18121011378
Email: sales@shydchem.com.cn
Company Name: Shanghai Longsheng chemical Co.,Ltd.  
Tel: 58099637 13585536065
Email: sales@shlschem.com

2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester manufacturers
2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester Basic information
Product Name:2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester
Synonyms:ETHYL-2-THIOMETHYL-PYRIMIDINE-5-CARBOXYLATE;Ethyl 2-(methylthio)-5-pyrimidinecarboxylate;2-METHYLTHIO-5-PYRIMIDINECARBOXYLIC ACID ETHYL ESTER;ETHYL-2-THIOMETHYL-PYRIMIDINE-5-CAROXYLATE;2-(Methylthio)-5-pyr;Ethyl 2-(methylsulphanyl)pyrimidine-5-carboxylate, Ethyl 2-(methylmercapto)pyrimidine-5-carboxylate;ETHYL-2-THIOM;2-methylthio-5-pyrimidinecarboxulic acid ethyl ester
CAS:73781-88-1
MF:C8H10N2O2S
MW:198.24
EINECS:1533716-785-6
Product Categories:Heterocycles;Heterocyclic Compound
Mol File:73781-88-1.mol
2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester Structure
2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester Chemical Properties
Melting point 38-40 °C
Boiling point 313.5±15.0 °C(Predicted)
density 1.24±0.1 g/cm3(Predicted)
storage temp. Storage temp. 2-8°C
pka-0.77±0.22(Predicted)
AppearanceWhite to off-white Solid
InChIInChI=1S/C8H10N2O2S/c1-3-12-7(11)6-4-9-8(13-2)10-5-6/h4-5H,3H2,1-2H3
InChIKeyLVNRRUKCFUSBDL-UHFFFAOYSA-N
SMILESC1(SC)=NC=C(C(OCC)=O)C=N1
CAS DataBase Reference73781-88-1(CAS DataBase Reference)
Safety Information
Risk Statements 36/37/38
Safety Statements 26-36/37/39
HS Code 29335990
MSDS Information
2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester Usage And Synthesis
Synthesis To the stirred solution of ethyl 4-chloro-2-(methylsulfanyl)pyrimidine-5-carboxylate (4.0 g, 17.2 mmol) in ethanol in a hydrogenation vessel, Na2CO3 (1.4 g, 16.7 mmol) and 10% Pd-C (2.0 g) were added and degassed for about 10 min. The reaction mixture was kept in a hydrogenation parr shaker (60 psi) for 48 h. The reaction mixture was filtered through the elite, washed with ethanol, and concentrated under reduced pressure to get 2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester as a pale yellow liquid (3.3 g. yield: 98.2 g, %).
2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester
References[1] Patent: US2016/333004, 2016, A1. Location in patent: Paragraph 0385
[2] Patent: US2008/227826, 2008, A1. Location in patent: Page/Page column 27-28
[3] Patent: WO2005/61465, 2005, A1. Location in patent: Page/Page column 61
[4] Patent: WO2008/53131, 2008, A1. Location in patent: Page/Page column 34-35
[5] Patent: WO2006/123121, 2006, A1. Location in patent: Page/Page column 17; 26
2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester Preparation Products And Raw materials
Raw materialsEthyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate-->Sodium carbonate-->Hydrogen-->Activated carbon-->Ethanol-->Palladium
Preparation Products2-Hydroxypyrimidine-5-carboxylic acid
Tag:2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester(73781-88-1) Related Product Information
1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine-carboxylate acid ethyl ester NICKEL AND VANADIUM IN RESIDUAL FUEL OIL 5-Pyrimidinecarboxylic acid Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate Ethyl 4-amino-2-(ethylthio)-5-pyrimidinecarboxylate Ethyl 4-amino-2-(methylthio)pyrimidine-5-carboxylate Ethyl 4-(benzylamino)-2-(methylthio)pyrimidine-5-carboxylate Ethyl 2-(methylsulfanyl)-4-piperidino-5-pyrimidinecarboxylate {[4-Amino-5-(ethoxycarbonyl)pyrimidin-2-yl]thio}acetic acid 5-Carbethoxy-4-chloro-2-ethyl-mercaptopyrimidine Ethyl 4-(methylamino)-2-(methylsulfanyl)-5-pyrimidinecarboxylate Ethyl 2-(methylsulfanyl)-4-morpholino-5-pyrimidinecarboxylate Ethyl 4-(4-chloroanilino)-2-(methylsulfanyl)-5-pyrimidinecarboxylate RARECHEM AL FH 0049 RARECHEM AL FB 0074 RARECHEM AL FF 0030 BUTTPARK 21\09-21 2-Ethylmercapto-5-carbethoxy-4-thiocyanopyrimidine