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| | 1-N-Boc-4-(4-bromophenyl)piperidine Basic information |
| Product Name: | 1-N-Boc-4-(4-bromophenyl)piperidine | | Synonyms: | 4-(4-BROMO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;N-Boc-4-(4-broMophenyl)piperidine;1-Boc-4-(4-Bromo-phenyl)-piperidine;1-Piperidinecarboxylic acid, 4-(4-bromophenyl)-, 1,1-dimethylethyl ester;4-(N-Boc-piperidin-4-yl)bromobenzene;1-N-Boc-4-(5-Bromophenyl)piperidine;4-(4-bromophenyl)piperidine-1-carboxylate;tert-butyl 4-(4-bromophenyl)piperidine-1-carboxylate 98%min | | CAS: | 769944-78-7 | | MF: | C16H22BrNO2 | | MW: | 340.26 | | EINECS: | | | Product Categories: | | | Mol File: | 769944-78-7.mol |  |
| | 1-N-Boc-4-(4-bromophenyl)piperidine Chemical Properties |
| Melting point | 41-42 °C | | Boiling point | 398.5±42.0 °C(Predicted) | | density | 1.283±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | -1.75±0.40(Predicted) | | Appearance | White to off-white Solid |
| | 1-N-Boc-4-(4-bromophenyl)piperidine Usage And Synthesis |
| Synthesis | Part A: 4-(4-bromophenyl)piperidine (960 mg, 4.0 mmol) was mixed with di-tert-butyl dicarbonate (960 mg, 4.4 mmol) in dichloromethane (DCM, 10 mL) at 0 °C. The reaction was completed by LC-MS analysis. After confirming the completion of the reaction by LC-MS analysis, additional dichloromethane (10 mL) was added to dilute the reaction mixture. Subsequently, the reaction mixture was washed with 1N HCl (10 mL) to remove unreacted feedstock and by-products. The organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated. The crude product was purified by fast column chromatography using gradient elution (0 to 100% hexane/ethyl acetate) conditions to afford the target compound 1-N-Boc-4-(4-bromophenyl)piperidine (Compound 2) as a white solid (1.36 g, 100% yield). HPLC-MS analysis showed retention time t R = 2.50 min (UV detection wavelength 2*nm), the The mass calculated value was C16H22BrNO2[M+H]+ 339.1 and the actual observed LCMS m/z was 284.1 (M+H-tBu). | | References | [1] Patent: WO2010/17060, 2010, A1. Location in patent: Page/Page column 31
[2] Patent: WO2009/158369, 2009, A1. Location in patent: Page/Page column 50
[3] Patent: WO2017/11776, 2017, A1. Location in patent: Paragraph 00698; 00699; 00700
[4] Patent: WO2007/70398, 2007, A1. Location in patent: Page/Page column 253
[5] Patent: WO2007/97937, 2007, A1. Location in patent: Page/Page column 188-189 |
| | 1-N-Boc-4-(4-bromophenyl)piperidine Preparation Products And Raw materials |
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